血清ACTN4对宫颈癌诊断及预后评价的价值  

The value of serum ACTN4 in the diagnosis and prognosis evaluation of cervical cancer

作　　者：应菲菲 YING Feifei(Departmet of Clinical Laboratory,Yancheng Maternity and Child Health Hospital,Yancheng,Jiangsu 224000,China)

机构地区：[1]盐城市妇幼保健院检验科,江苏盐城224000

出　　处：《国际检验医学杂志》2023年第11期1374-1377,1381,共5页International Journal of Laboratory Medicine

摘　　要：目的探讨血清α-肌动蛋白4(ACTN4)在新发宫颈癌患者中的表达,以及对诊断宫颈癌和评估生存预后的应用价值。方法选取2016年1月至2018年1月于该院就诊且首次病理检查确诊为宫颈癌的患者80例为宫颈癌组和宫颈上皮内瘤变(CIN)患者50例为CIN组,另选择同期入院进行体检的体检健康者60例为对照组。采用酶联免疫吸附试验(ELISA)检测外周血清ACTN4水平;采用受试者工作特征曲线分析ACTN4诊断宫颈癌的效能;采用Kaplan-Meier生存曲线表示累积生存率;采用单因素和多因素Cox比例风险回归模型筛选总生存期(OS)的独立危险因素。结果宫颈癌组血清ACTN4水平明显高于CIN组和对照组(P<0.05),CIN组和对照组ACTN4水平比较,差异无统计学意义(P>0.05)。血清ACTN4诊断宫颈癌的曲线下面积为0.856,灵敏度和特异度分别为85.6%和77.9%。宫颈癌患者国际妇产科联盟(FIGO)分期≥Ⅱb期比Ⅰa~<Ⅱb期、淋巴结转移阳性比阴性、宫颈浸润深度≥2/3比<2/3的ACTN4高表达率高,差异有统计学意义(P<0.05)。Kaplan-Meier生存曲线结果显示,ACTN4高表达患者的累积生存率明显低于ACTN4低表达患者(P<0.05)。单因素和多因素Cox回归分析结果显示,FIGO分期≥Ⅱb期、淋巴结转移阳性、宫颈浸润深度≥2/3和ACTN4高表达均是影响OS的独立危险因素(P<0.05)。结论宫颈癌患者血清ACTN4高表达可能参与了疾病的发生和发展过程,有望成为疾病诊断和判断疾病预后的重要生物标志物。Objective To investigate the expression of serumα-actin 4(ACTN4)in patients with newly diagnosed cervical cancer,and its application value in the diagnosis and prognosis evaluation of cervical cancer.Methods From January 2016 to January 2018,80 patients with cervical cancer diagnosed by the first pathological examination and 50 patients with cervical intraepithelial neoplasia(CIN)were selected as the cervical cancer group and the CIN group,and 60 healthy people who were admitted to the hospital for physical examination during the same period were selected as the control group.Serum ACTN4 levels were measured by enzyme-linked immunosorbent assay(ELISA).The receiver operating characteristic curve was used to analyze the efficacy of ACTN4 in the diagnosis of cervical cancer.The cumulative survival rate was expressed by Kaplan-Meier survival curve.Univariate and multivariate Cox proportional hazards regression models were used to screen the independent risk factors for overall survival(OS).Results The serum level of ACTN4 in cervical cancer group was significantly higher than that in CIN group and control group(P<0.05),but there was no significant difference between CIN group and control group(P>0.05).The area under the curve of serum ACTN4 in the diagnosis of cervical cancer was 0.856,the sensitivity and specificity were 85.6%and 77.9%,respectively.The ACTN4 high expression rate was higher in patients with FIGO stage≥Ⅱb thanⅠa-<Ⅱb,positive lymph node metastasis than negative,cervical invasion depth≥2/3 than<2/3,and the difference was statistically significant(P<0.05).Kaplan-Meier survival curve showed that the cumulative survival rate of patients with high ACTN4 expression was significantly lower than that of patients with low ACTN4 expression(P<0.05).Univariate and multivariate Cox regression analysis showed that FIGO stage≥Ⅱb,positive lymph node metastasis,depth of cervical invasion≥2/3 and high expression of ACTN4 were independent risk factors for OS(P<0.05).Conclusion The high expression of seru

关 键 词：宫颈癌 α-肌动蛋白4 病理特征 危险因素 总生存期 

分 类 号：R737.33[医药卫生—肿瘤]