遵循指南与共识 将观察与等待原则落实到韧带样纤维瘤临床治疗之中  

Follow the guidelines and consensus to implement the temporary waiting principle into the clinical treatment of desmoid-type fibromatosis

作　　者：于秀淳 侯子伟 YU Xiuchun;Hou Zi-wei(Department of Orthopedics,960th Hospital of PLA,Jina Shandong,250031,China)

机构地区：[1]中国人民解放军联勤保障部队第九六〇医院骨科,济南250031

出　　处：《中国骨与关节杂志》2023年第5期321-322,共2页Chinese Journal of Bone and Joint

摘　　要：韧带样纤维瘤(desmoid-type fibromatosis,DF)又称硬纤维瘤病、侵袭性纤维瘤病,是一种罕见的源于间充质细胞的克隆性成纤维细胞增殖病变[1]。DF的特征是浸润性生长和术后易复发,但不发生转移,生物学行为介于良恶性之间。长期以来手术是首选的治疗方式[2]。随着对DF的深入研究与临床疗效分析,逐步发现“观察与等待”是一种更合理的治疗策略[3-9]。现多种指南和共识[10-11]已将“观察与等待”列为DF的一线管理方案,显示了DF治疗理念的变化。Desmoid-type Fibromatosis is a benign and malignant borderline tumor originating from abnormal proliferation of mesenchymal cells, which is aggressive but rarely metastatic. Multiple treatments and individualized management are applied based on its variable disease course, indolent growth pattern, and poor local control. At present, temporary waiting is recognized as the first-line management plan for desmoid-type fibromatosis.Clinical symptoms and imaging changes are monitored through follow-up to determine whether the disease is stable or progressive. If the disease progresses during the waiting, local and systemic therapeutic interventions should be carefully selected according to individual circumstances, so that good disease control and long-term survival could be achieved.

关 键 词：纤维瘤 肿瘤 纤维组织 肿瘤 

分 类 号：R738.1[医药卫生—肿瘤]