Primary ovarian choriocarcinoma occurring in a postmenopausal woman:A case report  

作　　者：Guan-Lin Dai Fu-Rong Tang Dan-Qing Wang 

机构地区：[1]Department of Obstetrics and Gynecology,West China Second University Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China [2]Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University),Ministry of Education,Chengdu 610041,Sichuan Province,China

出　　处：《World Journal of Clinical Cases》2023年第15期3592-3598,共7页世界临床病例杂志

基　　金：Supported by Project of Science and Technology Department of Sichuan Province,No.2020YFS0131 and No.2016FZ0081.

摘　　要：BACKGROUND Nongestational ovarian choriocarcinoma(NGOC)is a rare but aggressive neoplasm with limited sensitivity to chemotherapy and a very poor prognosis.Few cases of NGOC have been reported,and there is limited information regarding its clinical features,treatment protocols,or prognosis.CASE SUMMARY A postmenopausal woman in her 5th decade of life visited our clinic because of abnormal vaginal bleeding and an abdominal mass.Although she had been menopausal for more than eight years and her last abortion occurred nine years ago,she had an increased level of serumβ-human chorionic gonadotropin(β-hCG).Thus,an ovarian neoplasm of trophoblastic origin was suspected,and exploratory laparotomy was performed.Based on the patient’s clinical history and the histopathological examination and immunohistochemistry results obtained postoperatively,we concluded that she most likely had primary NGOC.Cytoreductive surgery was performed in combination with adjuvant chemotherapy comprising bleomycin,etoposide,and cisplatin.Serumβ-hCG levels decreased to normal after two cycles,and there was no evidence of recurrence after four cycles of chemotherapy.CONCLUSION Even in postmenopausal women,ovarian choriocarcinoma should be considered in the initial differential diagnosis for an adnexal mass.

关 键 词：POSTMENOPAUSAL CHORIOCARCINOMA Ovarian neoplasm Non-gestational Trophoblastic Case report 

分 类 号：R737.31[医药卫生—肿瘤]