Co-existing squamous cell carcinoma and chronic myelomonocytic leukemia with ASXL1 and EZH2 gene mutations:A case report  

作　　者：Lai-Jun Deng Yang Dong Mi-Mi Li Chang-Gang Sun 

机构地区：[1]Department of Hematology,Weifang Hospital of Traditional Chinese Medicine,Weifang 261000,Shandong Province,China [2]Department of Clinical Pharmacy,Weifang Hospital of Traditional Chinese Medicine,Weifang 261000,Shandong Province,China [3]Department of Pathology,Weifang Hospital of Traditional Chinese Medicine,Weifang 261000,Shandong Province,China

出　　处：《World Journal of Clinical Cases》2023年第15期3643-3650,共8页世界临床病例杂志

摘　　要：BACKGROUND Chronic myelomonocytic leukemia(CMML),a rare clonal hematopoietic stem cell disorder characterized by myelodysplastic syndrome and myeloproliferative neoplasms,has a generally poor prognosis,and easily progresses to acute myeloid leukemia.The simultaneous incidence of hematologic malignancies and solid tumors is extremely low,and CMML coinciding with lung malignancies is even rarer.Here,we report a case of CMML,with ASXL1 and EZH2 gene mutations,combined with non-small cell lung cancer(lung squamous cell carcinoma).CASE SUMMARY A 63-year-old male,suffering from toothache accompanied by coughing,sputum,and bloody sputum for three months,was given a blood test after experiencing continuous bleeding resulting from a tooth extraction at a local hospital.Based on morphological results,the patient was diagnosed with CMML and bronchoscopy was performed in situ to confirm the diagnosis of squamous cell carcinoma in the lower lobe of the lung.After receiving azacitidine,programmed cell death protein 1,and platinum-based chemotherapy drugs,the patient developed severe myelosuppression and eventually fatal leukocyte stasis and dyspnea.CONCLUSION During the treatment and observation of CMML and be vigilant of the growth of multiple primary malignant tumors.

关 键 词：Squamous cell carcinoma Chronic myelomonocytic leukemia Myeloproliferative neoplasms MYELODYSPLASTIC ASXL1 gene mutations EZH2 gene mutations Case report 

分 类 号：R733.72[医药卫生—肿瘤]