抗SOX-1抗体阳性副肿瘤性脊髓病一例  

Case report:paraneoplastic myelopathy with SOX-1 antibodies

作　　者：杨正芳 张忠敏 向修志 尹昌浩 赵维纳 Yang Zhengfang;Zhang Zhongmin;Xiang Xiuzhi;Yin Changhao;Zhao Weina(Department of Neurology,Hongqi Hospital Affiliated to Mudanjiang Medical University,Heilongjiang 157000,China)

机构地区：[1]牡丹江医学院附属红旗医院,黑龙江157000

出　　处：《脑与神经疾病杂志》2023年第5期286-289,共4页Journal of Brain and Nervous Diseases

摘　　要：目的探讨副肿瘤性脊髓病(PM)的临床特点,以提高对该病的诊断水平。方法分析1例PM患者的病历资料。结果 62岁男性患者以双下肢麻木无力起病,呈亚急性进展,脑脊液副肿瘤综合征抗体示:抗SOX-1抗体IgG阳性(+),结合CT及增强磁共振(MRI)等检查,诊断为PM。结论 副肿瘤性脊髓病是由于全身性或潜在的恶性肿瘤的远隔效应从而造成脊髓损伤的一种神经系统副肿瘤综合征,提高对该病的认识,有助于早期诊断,通过检测相关特异性抗体指导疾病的早期治疗。Objective To explore the clinical features of PM in order to improve the diagnosis of this disease.Methods Analysis of the medical history of a patient with PM.Results A 62-year-old male patient with numbness and weakness in both lower extremities started,showed subacute progression.Cerebrospinal fluid examination showed positive SOX-1 antibodies IgG(+).Combined with CT and enhanced MRI,the diagnosis was PM.Conclusions PM is a rare PNS that results in spinal cord injury due to the distal septal effects of a systemic or potentially malignant tumor.Increased awareness of the disease will help in early diagnosis and guide early treatment of the disease by testing for relevant specific antibodies.

关 键 词：神经系统副肿瘤综合征 副肿瘤性脊髓病 抗SOX-1抗体 

分 类 号：R744[医药卫生—神经病学与精神病学]