托吡酯和普萘洛尔预防儿童偏头痛的临床疗效观察  

Topiramate and propranolol in the prevention of pediatric migraine

作　　者：司友锋 马敏敏 Si Youfeng;Ma Minmin(Department of Neurology,Feicheng Hospital of Yiying Health Group,Shandong 271608,China)

机构地区：[1]山东颐养健康集团肥城医院,山东271608

出　　处：《脑与神经疾病杂志》2023年第5期298-302,共5页Journal of Brain and Nervous Diseases

摘　　要：目的 比较和评价托吡酯和普萘洛尔在儿童偏头痛预防中的临床疗效。方法 采用随机、对照、前瞻性的研究方法,共纳入了93例5~17岁的偏头痛患儿进行研究。将患儿随机分为两组,其中A组46例给予托吡酯50mg·d^(-1)治疗,B组47例给予普萘洛尔1 mg·kg^(-1)·d^(-1)治疗,持续观察3个月。分别记录患儿的在治疗后第1个月,第2个月及第3个月头痛发作次数、严重程度、持续时间及不良反应。结果治疗3个月后,托吡酯组和普萘洛尔组患儿的头痛发作频率、严重程度和持续时间均较用药前显著降低,在治疗的第2个月和第3个月,托吡酯每月头痛发作频率及持续时间较普萘洛尔下降更显著(P<0.05);在治疗的第3个月,托吡酯组患儿的头痛严重程度(VAS评分)低于普萘洛尔组(P<0.05)。两组均未出现严重不良反应。结论 托吡酯和普萘洛尔均能有效的减少儿童偏头痛发作频率,严重程度及持续时间;且托吡酯比普萘洛尔效果更为显著。两种药物的安全性良好。Objective The present study aimed to compare the efficacy of topiramate with propranolol in the prophylaxis of pediatric migraine.Methods A randomized controlled and prospective trial was conducted.A total of 93 pediatric patients with episodic migraine were randomly allocated to 2 independent groups to receive either 50 mg·d^(-1)topiramate(group A)or 1 mg·kg^(-1)·d^(-1)propranolol(group B)as prophylactic drugs for 3months.The headache days per month.migraine headache severity(aseessed by Visual Analogue Scale,VAS),duration of migraine attacks,and adverse reactions were assessed respectively before and 1,2,3 months after treatment.Results After 3 months treatment,the number of headache days.VAS,and duration of migraine attacks in both groups all decreased.The headache days per month and duration of migraine attacks of topiramate group were significantly lower than propranolol group after continuous 2 and 3 months treatment(P<0.05).The migraine headache severity of topiramate group was significantly lower than propranolol group after continuous 3 months treatment(P<0.05).No serious adverse effects of medications were observed in both groups.Conclusion The present study proved that both lopiramate and propranolol could signilicanlly reduce pediatric migraine headache frequency,severity,and duration.However,topiramate is more effective than propranolol for pediatric migraine prophylaxis.Both drugs were safe for children.

关 键 词：托吡酯 普萘洛尔 儿童偏头痛 预防治疗 

分 类 号：R747.2[医药卫生—神经病学与精神病学]