循环肿瘤细胞的检测及其在乳腺癌中的应用  

Detection of circulating tumor cells and its application in breast cancer

作　　者：冯雪园 韩萌萌 马宁[1] Feng Xueyuan;Han Mengmeng;Ma Ning(The Second Department of Breast Surgery,Baoding NO.1 Central Hospital,Baoding 071000,China)

机构地区：[1]保定市第一中心医院乳腺外二科,071000

出　　处：《中华普通外科学文献（电子版）》2023年第3期231-236,共6页Chinese Archives of General Surgery(Electronic Edition)

摘　　要：循环肿瘤细胞(CTC)是从原发肿瘤脱落并在血液中循环的细胞,其转移和继发与肿瘤的形成、癌症相关死亡密切相关。在过去的十年里,许多基于CTC的生物学和物理差异的分离和检测方法已经发展起来。最近的研究表明,CTC在原发性和转移性环境中都可能成为预测乳腺癌生存和治疗监测的关键指标之一,其表征可能成为生物疗法的新靶点。Circulating tumor cells(CTC)are cells that fall off from primary tumors and circulate in the blood,and their metastasis and formation of a secondary tumor are closely associated with cancer-related death.In the last decade,many detection methods based on biological and physical differences in CTC have been developed.Recent studies indicate that CTC have the potential to predict prognosis in both primary and metastatic settings,and CTC may be one of the key indicators to predicting survival and therapeutic monitoring in breast cancer,and their characterization may be novel targets for biological therapies.

关 键 词：循环肿瘤细胞 检测方法 乳腺肿瘤 预后 

分 类 号：R737.9[医药卫生—肿瘤]