Risk factors of recurrent choledocholithiasis following therapeutic endoscopic retrograde cholangiopancreatography  

作　　者：Lin Li Jing Wang Cheng-Cheng Tong Chi-Yi He 

机构地区：[1]Department of Gastroenterology,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China

出　　处：《Hepatobiliary & Pancreatic Diseases International》2023年第3期282-287,共6页国际肝胆胰疾病杂志（英文版）

基　　金：supported by a grant from the Anhui Province Key Research and Development Program Project(201904a07020028)。

摘　　要：Background:The risk factors for the recurrent choledocholithiasis after endoscopic retrograde cholangiopancreatography(ERCP)have not been well studied.The aim of this study was to explore the risk factors of recurrent choledocholithiasis.Methods:We carried out a retrospective analysis of data collected between January 1,2010 and January 1,2020.Univariate analysis and multivariate analysis were used to explore the independent risk factors of recurrent choledocholithiasis following therapeutic ERCP.Results:In total,598 patients were eventually selected for analysis,299 patients in the recurrent choledocholithiasis group and 299 patients in the control group.The overall rate of recurrent choledocholithiasis was 6.91%.Multivariate analysis showed that diabetes[odds ratio(OR)=3.677,95%confidence interval(CI):1.875-7.209;P<0.001],fatty liver(OR=4.741,95%CI:1.205-18.653;P=0.026),liver cirrhosis(OR=3.900,95%CI:1.358-11.201;P=0.011),history of smoking(OR=3.773,95%CI:2.060-6.908;P<0.001),intrahepatic bile duct stone(OR=4.208,95%CI:2.220-7.976;P<0.001),biliary stent(OR=2.996,95%CI:1.870-4.800;P<0.001),and endoscopic papillary balloon dilation(EPBD)(OR=3.009,95%CI:1.921-4.715;P<0.001)were independent risk factors of recurrent choledocholithiasis.However,history of drinking(OR=0.183,95%CI:0.099-0.337;P<0.001),eating light food frequently(OR=0.511,95%CI:0.343-0.760;P=0.001),and antibiotic use before ERCP(OR=0.315,95%CI:0.200-0.497;P<0.001)were independent protective factors of recurrent choledocholithiasis.Conclusions:Patients with the abovementioned risk factors are more likely to have recurrent CBD stones.Patients who eat light food frequently and have a history of drinking are less likely to present with recurrent CBD calculi.

关 键 词：RECURRENCE CHOLEDOCHOLITHIASIS Endoscopic retrograde CHOLANGIOPANCREATOGRAPHY 

分 类 号：R575.62[医药卫生—消化系统]