PVP及ITR联合治疗肿瘤性椎体压缩性骨折对术后疼痛及椎体功能的影响  

Effect of PVP and ITR combined treatment on postoperative pain and vertebral function of neoplastic vertebral compression fracture

作　　者：李阳[1] 王义清[1] 任莹[1] 夏樊军[1] LI Yang;WANG Yiqing;REN Ying;XIA Fanjun(Department of Interventional Radiology,Xi′an Central Hospital of Shaanxi,Xi′an,Shaanxi 710003,China)

机构地区：[1]陕西省西安市中心医院介入科,陕西西安710003

出　　处：《检验医学与临床》2023年第11期1564-1567,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨经皮椎体成形术(PVP)及介入肿瘤摘除术(ITR)联合治疗肿瘤性椎体压缩性骨折对术后疼痛及椎体功能的影响。方法选择2021年4月至2022年4月该院介入科收治的肿瘤性椎体压缩性骨折患者88例作为研究对象,按照不同治疗方法分为观察组(PVP联合ITR治疗,44例)和对照组(PVP治疗,44例)。比较两组患者手术时间、术中出血量、骨水泥注入量、术后下地时间、住院时间、术后并发症,以及手术前后视觉模拟疼痛量表(VAS)评分、5-羟色胺(5-HT)水平、皮质醇(Cor)水平、Oswestry功能障碍指数(ODI)、Barthel指数(BI)等。结果观察组患者骨水泥注入量多于对照组,术后并发症发生率低于对照组,差异均有统计学意义(P<0.05)。两组患者术后1、3、6个月VAS评分均低于术前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。两组患者术后3个月5-HT、Cor水平均高于术前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。两组患者术后3个月ODI均低于术前,且观察组低于对照组,差异均有统计学意义(P<0.05)。两组患者术后3个月BI均高于术前,且观察组高于对照组,差异均有统计学意义(P<0.05)。结论PVP及ITR联合治疗肿瘤性椎体压缩性骨折可有效缓解患者术后疼痛,改善患者椎体功能和生活质量,减少骨水泥渗漏。Objective To investigate the effect of percutaneous vertebral plasty(PVP)and interventional tumor removal(ITR)combined treatment on postoperative pain and vertebral function of neoplastic vertebral compression fracture.Methods A total of 88 patients with neoplastic vertebral compression fractures admitted to the hospital from April 2021 to April 2022 were selected as research objects.According to the treatment methods,they were divided into observation group(PVP combined with ITR treatment,44 cases)and control group(PVP treatment,44 cases).The operation time,intraoperative blood loss,bone cement injection volume,postoperative ground time,hospital stay and postoperative complications were compared between the two groups.The visual analogue scale(VAS)scores,5-hydroxytryptamine(5-HT)levels,cortisol(Cor)levels,Oswestry disability index(ODI)and Barthel index(BI)before and after operation were compared between the two groups.Results The amount of bone cement injection volume in the observation group was higher than that in control group,and the incidence of postoperative complications was lower than that in the control group,and the differences were statistically significant(P<0.05).The VAS scores of the two groups at 1,3 and 6 months after operation were lower than those before operation,and the VAS scores of observation group were lower than those of control group,and the differences were statistically significant(P<0.05).The 5-HT and Cor levels in the two groups 3 months after operation were higher than those before operation,and those in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).The ODI of the two groups 3 months after operation was lower than that before operation,and the ODI of the observation group was lower than that of control group,and the difference was statistically significant(P<0.05).The BI of the two groups 3 months after operation was higher than that before operation,and that of observation group was higher than that of control g

关 键 词：经皮椎体成形术 介入肿瘤摘除术 肿瘤性椎体压缩性骨折 疼痛 椎体功能 

分 类 号：R738[医药卫生—肿瘤] R730.56[医药卫生—临床医学]