肺癌转移相关信号通路研究进展  

Development of metastasis-related signaling pathways in lung cancer

作　　者：周浩楠 呼永华[1,2,3] 张志明 王晓宇 仝建宁 陈昊 ZHOU Haonan;HU Yonghua;ZHANG Zhiming;WANG Xiaoyu;TONG Jianning;CHEN Hao(The First Clinical Medical College of Gansu University of Chinese Medicine,Lanzhou730000,China;Second Clinical Medical College of Lanzhou University,Lanzhou730030,China;Department of Oncology,Affiliated Hospital of Gansu University of Chinese Medicine,Lanzhou730000,China;Famous Medical Museum,The First Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou730050,China)

机构地区：[1]甘肃中医药大学第一临床医学院,甘肃兰州730000 [2]兰州大学第二临床医学院,甘肃兰州730030 [3]甘肃中医药大学附属医院肿瘤科,甘肃兰州730000 [4]甘肃中医药大学第一附属医院名医馆,甘肃兰州730050

出　　处：《社区医学杂志》2023年第12期648-652,共5页Journal Of Community Medicine

基　　金：甘肃省自然科学基金(17JR5A169);甘肃省科技厅项目(18JR2FA002);甘肃省中医药管理局“国家中医特色优势针灸专科”项目;兰州市科技局新冠肺炎防控技术研究项目(2020-XG-27);甘肃省卫生行业项目(GSWSKY2020-60);甘肃省高校开放基金(FZYX15-16-8);兰州市科技计划(2021-1-99)。

摘　　要：肺癌的发病率和死亡率居全球癌症第1位,在我国的发病率也居首位,而肺癌发生转移是治疗失败的主要原因,如何阻断肺癌转移已成为亟需解决的问题。现已发现诸多信号通路与肿瘤的发生、发展、转移有着密切关系。本研究总结其中主要的信号通路TGF-β/Smad、PI3K/AKT/mTOR、JAK/STAT、Wnt/β-catenin与肺癌转移的最新研究进展。以“肺癌、信号通路”为关键词,检索2018-01-01-2022-12-31中国知网及PubMed相关文献。纳入标准:肺癌和TGF-β/Smad信号通路的研究;肺癌和PI3K/AKT/mTOR信号通路的研究;肺癌和JAK/STAT信号通路的研究;肺癌和Wnt/β-catenin信号通路的研究。排除标准:肺癌和其他信号通路的相关研究。最终纳入分析文献51篇。结果表明,肺癌的发生和诸多信号通路相关,其中与TGF-β/Smad、PI3K/AKT/mTOR、JAK/STAT、Wnt/β-catenin信号通路密切相关。TGF-β/Smad、PI3K/AKT/mTOR、JAK/STAT、Wnt/β-catenin信号通路广泛参与了肺癌肿瘤细胞的生长、分化、侵袭、转移等多种过程。进一步研究与肺癌转移的相关通路,明确其各自的作用机制,有望发现更多有效的转移过程中的靶点。The incidence and mortality of lung cancer rank first worldwide and also rank first in incidence in our country,while lung cancer metastasis is a major cause of treatment failure,and how to block lung cancer metastasis has become a much-needed problem.Now,many signaling pathways have been found to be closely related to tumor development and metastasis.This review summarized the recent research progress on several major signaling pathways,including TGF-p/Smad,PI3K/Akt/mTOR,JAK/stat,and Wnt/β-catenin,and lung cancer metastasis.Using"lung cancer,signaling pathway"as keywords,we searched relevant literature in China National Knowledge Infrastructure and PubMed from January 1,2018 to December 31,2022.Inclusion criteria:studies of lung cancer and TGF-p/Smad signaling pathways;studies on lung cancer and the PI3K/Akt/mTOR signaling pathway;studies of lung cancer and JAK/STAT signaling pathways;lung cancer and Wnt/β-catenin signaling pathway.Exclusion criteria:relevant studies of lung cancer and other signaling pathways.Fifty-one articles were finally included in the analysis.The results showed that the carcinogenesis of lung cancer and many signaling pathways were related,among which,TGF-β/Smad signaling pathway,PI3K/Akt/mTOR signaling pathway,JAK/STAT signaling pathway,Wnt/β-catenin signaling pathway were closely related.TGF-β/Smad signaling pathway,PI3K/Akt/mTOR signaling pathway,JAK/STAT signaling pathway,Wnt/β-catenin signaling pathway were widely involved in many processes including lung cancer tumor cell growth,differentiation,invasion,metastasis.Further research on the related pathways with lung cancer metastasis,and clarifying their respective mechanisms of action will hopefully lead to the discovery of more effective targets in the metastatic process.

关 键 词：肺癌 转移 信号通路 综述文献 

分 类 号：R734.2[医药卫生—肿瘤]