海南省汉族与黎族经典型卡波西肉瘤临床及病理特征比较  

Comparison of clinical and pathological features of classic Kaposi sarcoma of Han nationality and Li nationality in Hainan

作　　者：张海航 吴祎 曾江正[1] 胡波心 王丽茹 卢彦达[1] ZHANG Haihang;WU Yi;ZENG Jiangzheng;HU Boxin;WANG Liru;LU Yanda(Department of Medical Oncology,First Affiliated Hospital of Hainan Medical College,Haikou570102,China;Department of Pathology,Second Affiliated Hospital of Hainan Medical College,Haikou570216,China;Department of Obstetrics and Gynecology,Hainan Provincial People's Hospital,Haikou570311,China)

机构地区：[1]海南医学院第一附属医院肿瘤内科,海南海口570102 [2]海南医学院第二附属医院病理科,海南海口570216 [3]海南省人民医院妇产科,海南海口570311

出　　处：《中华肿瘤防治杂志》2023年第8期456-460,共5页Chinese Journal of Cancer Prevention and Treatment

基　　金：海南省自然基金高层次人才项目(821RC695)。

摘　　要：目的探讨海南省汉族与黎族经典型卡波西肉瘤(CKS)的临床及肿瘤病理特征之间的差异。方法选取1999-01-01-2021-06-30分别在海南医学院第一附属医院、海南医学院第二附属医院和海南省人民医院诊治的39例CKS患者,包括23例汉族患者(汉族CKS组)和16例黎族患者(黎族CKS组)。汉族患者中,男18例,女5例;年龄<65岁6例,≥65岁17例;黎族患者中,男13例,女3例;年龄<65岁6例,≥65岁10例。采用χ^(2)检验或Fisher精确算法比较汉族和黎族患者的临床病理资料。结果汉族CKS组与黎族CKS组比较,其皮损面积(P=0.039)、临床分期(P=0.007)和血管裂隙(χ^(2)=5.888,P=0.015)差异均有统计学意义。CKS免疫组化总共纳入25例,汉族和黎族的CD34阳性构成比均为100.0%(25/25),而黎族和汉族人疱疹病毒8型(HHV-8)阳性构成比分别为53.8%(7/13)和50.0%(6/12)。结论海南省的CKS患者以老年男性居多,>50.0%的病例中能检测到HHV-8。与汉族CKS相比,黎族CKS具有皮损面积较大、临床分期较晚和血管裂隙样改变较多的特点。Objective To explore the differences between the clinical and tumor pathological features of Classic Kaposi sarcoma(CKS)between Han and Li nationality in Hainan.Methods A total of 39patients with CKS were treated in 3different medical institutions in Hainan from 1999-01-01to 2021-06-30.All cases include 23Han nationality and 16Li nationality patients.Totally 23Han nationality,including 18males,5females,6aged<65and 17≥65years.There were 16cases of Li nationality patients,including 13males,3females,6cases aged<65years old,and 10cases≥65years old.Results The male-female composition ratios of CKS cases in Hainan were 79.5%(31/39)and 20.5%(8/39),respectively.The composition ratios of Han nationality and Li nationality patients were 59.0%(23/39)and 41.0%(16/39),respectively.The composition ratios of patients aged≥65and<65years were 69.2%(27/39)and 40.8%(12/39),respectively.Compared with the Li nationality patients,the lesion area(P=0.039),clinical stage(P=0.007)and vascular fissure(χ2=5.888,P=0.015)were statistically significant.In addition,a total of 25cases were included in the immunohistochemical clinical manifestations of CKS,and the positive composition ratio of CD34was 100.0%(25/25)for Han nationality and Li nationality patients,while the positive composition ratio of human herpesvirus type 8(HHV-8)was 53.8%(7/13)and 50.0%(6/12),respectively.Conclusions CKS patients in Hainan are predominantly elderly men,and HHV-8has been detected in more than 50.0%of the cases.Compared with the Han nationality,the Li nationality CKS are characterized by larger skin area,later clinical stage and more changes in blood vessel fissure.

关 键 词：经典型卡波西肉瘤 临床病理特征 黎族 汉族 海南 

分 类 号：R732.2[医药卫生—肿瘤]