大分割容积旋转调强放疗治疗晚期非小细胞肺癌的临床研究  

Clinical effect of large segmentation volume rotation intensity modulated radiotherapy for advanced non-small cell lung cancer

作　　者：段锋[1] Duan Feng(Department of Radiotherapy,the First Affliated Hospital of Henan University of Science and Technology,Luoyang 471000,China)

机构地区：[1]河南科技大学第一附属医院放疗科,洛阳471000

出　　处：《临床医学》2023年第3期15-18,共4页Clinical Medicine

摘　　要：目的 探讨大分割容积旋转调强放疗治疗晚期非小细胞肺癌的临床效果。方法 选取2019年7月至2021年8月河南科技大学第一附属医院收治的82例晚期非小细胞肺癌患者为研究对象。按照治疗方法分为研究组和对照组,每组41例。两组均进行顺铂联合依托泊苷方案治疗,在此基础上对照组采用常规分割动态调强放射治疗,研究组采用大分割容积旋转调强放射治疗,两组均5次/周,连续治疗6周。放疗结束后1个月评估两组患者临床疗效、肿瘤标志物[血清癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)及糖类抗原125(CA125)]水平、生存状况以及不良反应发生率。结果 治疗后1个月,研究组治疗总有效率(97.56%,40/41)高于对照组(80.49%,33/41),差异有统计学意义(χ^(2)=4.493,P=0.034<0.05)。治疗后1个月,两组血清CEA、NSE、CA125水平均低于治疗前,且研究组血清CEA、NSE、CA125水平低于对照组,差异有统计学意义(P<0.05)。研究组生存时间为3~12个月,中位总生存期为12个月(95%置信区间:10.915~13.085),1年生存率为82.93%(34/41);对照组生存时间为3~12个月,中位总生存期为10个月(95%置信区间:8.753~11.247),1年生存率为60.98%(25/41),两组比较差异有统计学意义(χ^(2)=3.875,P=0.049)。研究组不良反应发生率(7.32%,3/41)低于对照组(34.15%,14/41),差异有统计学意义(χ^(2)=8.979,P=0.003<0.05)。结论 在晚期非小细胞肺癌患者的治疗中,大分割容积旋转调强放疗的临床疗效显著,能降低肿瘤标志物水平表达,延长患者生存时间,且安全性高。Objective To investigate the clinical effect of large volume rotation-intensity modulated radiotherapy on advanced non-small cell lung cancer.Methods Eighty-two patients with advanced non-small cell lung cancer admitted to the First Affiliated Hospital of Henan University of Science and Technology from July 2019 to August 2021 were selected as the study subjects.According to the treatment method,they were divided into study group and control group,with 41 cases in each group.Both groups were treated with cisplatin and etoposide.The control group was treated with conventional fractionated dynamic intensity modulated radiotherapy,and the study group was treated with large volume rotating intensity modulated radiotherapy.All patients were treated 5 times per week for 6 weeks.The clinical efficacy,tumor markers[serum carcinoembryonic antigen(CEA),neuron-specific enolase(NSE)and carbohydrate antigen 125(CA125)],survival status and the incidence of side effects of the two groups were evaluated one month after radiotherapy.Results One month after treatment,the total effective rate of treatment in the study group(97.56%,40/41)was higher than that in the control group(80.49%,33/41),the difference was significant(2=4.493,P=0.034<0.05).One month after treatment,the levels of serum CEA,NSE and CA125 in the two groups were lower than those before treatment,and the levels of serum CEA,NSE and CA125 in the study group were lower than those in the control group,the differences were significant(P<0.05).In the study group,the survival time was 3 to 12 months,the median total survival time was 12 months(95%confidence interval:10.915 to 13.085),and the one-year survival rate was 82.93%(34/41);the survival time of the control group was 3 to 12 months,the median total survival time was 10 months(95%confidence interval:8.753 to 11.247),and the one-year survival rate was 60.98%(25/41),the differences between the two groups were significant(X^(2)=3.875,P=0.049).The incidence of side efects in the study group(7.32%,3/41)was lower than tha

关 键 词：晚期非小细胞肺癌 大分割容积旋转调强放疗 动态调强放疗 

分 类 号：R734.2[医药卫生—肿瘤]