幽门螺杆菌感染患者胃黏膜病变表现与胃蛋白酶原和胃泌素-17水平的相关性  

Correlation between manifestations of gastric mucosal lesions and levels of pepsinogen and gastrin-17 in patients with Helicobacter pylori infection

作　　者：韩文鹏 刘静 王浩文 HAN Wenpeng;LIU Jing;WANG Haowen(Department of Gastroenterology,Qingdao Chengyang People's Hospital,Qingdao,Shandong 266109,China;Department of Obstetrics and Gynecology,Qingdao Chengyang People's Hospital,Qingdao,Shandong 266109,China)

机构地区：[1]青岛市城阳区人民医院消化内科,山东青岛266109 [2]青岛市城阳区人民医院妇产科,山东青岛266109

出　　处：《热带医学杂志》2023年第4期488-492,共5页Journal of Tropical Medicine

基　　金：青岛市医药科研指导计划(2020-WJZD210)。

摘　　要：目的分析幽门螺杆菌(Hp)感染患者胃黏膜病变表现与胃蛋白酶原(PG)和胃泌素-17(G-17)水平变化的关系。方法选择2019年2月-2021年5月青岛市城阳区人民医院诊治的胃黏膜病变患者101例作为观察对象,采用13C尿素呼气试验联合免疫胶乳比浊法测定Hp抗体水平判断Hp感染情况。按照Hp感染情况分为Hp阳性组(n=71)和Hp阴性组(n=30),比较其胃黏膜病变情况,并采用酶联免疫吸附法测定上述患者胃蛋白酶原Ⅰ(PGⅠ)和胃蛋白酶原Ⅱ(PGⅡ)以及二者比值(PGR)和G-17水平,比较上述不同分组PGⅠ、PGⅡ和PGR及G-17水平。采用Spearman相关性分析PGⅠ、PGⅡ、PGR及G-17水平与Hp感染和胃黏膜病变程度的关系,采用logistic回归分析Hp感染患者胃黏膜病变的危险因素。结果Hp阳性组饮食结构不合理患者多于Hp阴性组,胃黏膜病变程度严重例数高于Hp阴性组,差异均有统计学意义(χ^(2)=3.938,U=2.240,P均<0.05)。Hp阳性组PGⅠ和PGR均较Hp阴性组降低,且G-17水平高于Hp阴性组患者,差异均有统计学意义(t=3.612、3.025、3.277,P均<0.05)。Hp阳性患者PGⅠ、PGR水平随着胃黏膜病情加重而降低,G-17水平随着胃黏膜病变加重而升高(F=6.703、4.418、26.634,P均<0.05),不同病变组患者PGⅡ水平比较,差异无统计学意义(F=0.310,P>0.05)。Spearman相关性显示,PGⅠ、PGR与Hp感染成负相关(r=-0.476、-0.531,P均<0.05),与胃黏膜病变程度也成负相关(r=-0.523、-0.509,P均<0.05);G-17水平与Hp感染和胃黏膜病变程度均成正相关(r=0.489、0.476,P均<0.05)。结论饮食结构不合理、Hp阳性和PGI与PGR水平下降以及G-17水平上升是胃黏膜病变的危险因素。Objective To analyze the relationship between manifestations of gastric mucosal lesions and levels of pepsinogen(PG)and gastrin-17(G-17)in patients with Helicobacter pylori(Hp)infection.Methods A total of 101patients with gastric mucosal lesions diagnosed and treated in the hospital between February 2019 and May 2021 were selected as observation subjects.13C urea breath test combined with immunolatex turbidimetry was used to determine the Hp antibody level to judge the Hp infection.According to the Hp infection status,the patients were divided into Hp-positive group(n=71)and Hp-negative group(n=30).The status of gastric mucosal lesions were compared,and enzyme linked immunosorbent assay was applied to detect the pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ)and the ratio of the two(PGR)and gastrin-17(G-17),and the levels of PGⅠ,PGⅡ,PGR and G-17 were compared between the groups.Spearman correlation analysis was adopted to analyze the relationship between levels of PGⅠ,PGⅡ,PGR and G-17 and Hp infection and degree of gastric mucosal lesions.Logistic regression analysis was used to analyze the risk factors of gastric mucosal lesions in patients with Hp infection.Results The number of patients with unreasonable diet in Hp-positive group was more than that in Hp-negative group(P<0.05).The number of patients with severe gastric mucosal lesions was more in Hp-positive group than that in Hp-negative group(P<0.05).The PGⅠand PGR in Hp-positive group were lower than those in Hp-negative group while the level of G-17 was higher than that in Hp-negative group(P<0.05).The levels of PGⅠand PGR in Hp-positive patients were decreased with gastric mucosal lesions aggravated while G-17 level was increased(P<0.05),and there was no statistical significance in differences in PGⅡlevels among patients with different lesions(P>0.05).Spearman correlation results showed PGⅠand PGR were negatively correlated with Hp infection(r=-0.476,-0.531,all P<0.05)and degree of gastric mucosal lesions(r=-0.523,-0.509,all P<0.05).G-17 level w

关 键 词：幽门螺杆菌 胃黏膜病变 胃镜活检 胃蛋白酶原 

分 类 号：R573[医药卫生—消化系统]