肝瞬时弹性成像指标、脾脏厚度、门静脉内径及FIB4、APRI与肝硬化食管静脉曲张程度的相关性  

Correlation among Hepatic Transient Elastography Index,Spleen Thickness,Portal Vein Inner Diameter,FIB4,APRI and the Degree of Esophageal Varices in Liver Cirrhosis

作　　者：程晓静[1] CHENG Xiaojing(The Second People's Hospital of Tianjin,Tianjin 300192,China)

机构地区：[1]天津市第二人民医院,天津300192

出　　处：《中外医学研究》2023年第14期75-78,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探究肝瞬时弹性成像指标、脾脏厚度、门静脉内径及纤维化-4指数(FIB4)、天门冬酸氨基转移酶与血小板比率指数(APRI)与肝硬化食管静脉曲张程度的相关性。方法:选取2020年12月—2022年2月天津市第二人民医院收治的40例肝硬化重度食管静脉曲张患者为A组,40例肝硬化中度食管静脉曲张患者为B组,40例肝硬化轻度食管静脉曲张患者为C组,40例肝硬化无食管静脉曲张患者为D组。四组均进行肝瞬时弹性成像检测、丙氨酸氨基转移酶(ALT)、天门冬酸氨基转移酶(AST)及血小板(PLT)检测,并计算FIB4及APRI。比较四组肝瞬时弹性成像指标、脾脏厚度、门静脉内径及FIB4、APRI,采用Spearman秩相关分析上述检测指标与肝硬化食管静脉曲张严重程度的关系。结果:A组、B组及C组的肝硬度值、脾硬度值、脾脏厚度及门静脉内径、FIB4及APRI均显著高于D组,A组与B组肝硬度值、脾硬度值、脾脏厚度及门静脉内径、FIB4及APRI均显著高于C组,A组肝硬度值、脾硬度值、脾脏厚度及门静脉内径、FIB4及APRI均著高于B组,差异有统计学意义(P<0.05)。Spearman秩相关分析结果显示,肝硬度值、脾硬度值、脾脏厚度、门静脉内径及FIB4、APRI均与肝硬化食管静脉曲张程度呈正相关(P<0.05)。结论:肝硬化食管静脉曲张患者的肝瞬时弹性成像指标、脾脏厚度、门静脉内径及FIB4、APRI表达显著异常,且上述指标与食管静脉曲张的程度密切相关,因此其在肝硬化食管静脉曲张患者中的检测价值较高。Objective:To investigate the correlation among hepatic transient elastography index,spleen thickness,portal vein inner diameter,fibrosis 4 index(FIB4),aspartate aminotransferase to platelet ratio index(APRI)and the degree of esophageal varices in liver cirrhosis.Method:From December 2020 to February 2022,40 patients with severe esophageal varices in liver cirrhosis admitted to the Second People's Hospital of Tianjin were selected as group A,40 patients with moderate esophageal varices in liver cirrhosis were selected as group B,40 patients with mild esophageal varices in liver cirrhosis were selected as group C,and 40 patients without esophageal varices in liver cirrhosis were selected as group D.Hepatic transient elastography,alanine aminotransferase(ALT),aspartate aminotransferase(AST),platelet(PLT)detection were performed in all the four groups,and FIB4 and APRI were calculated.The hepatic transient elastometry indexes,spleen thickness,portal vein inner diameter,FIB4 and APRI of four groups were compared.Spearman rank correlation was used to analyze the relationship among the above detection indexes and the severity of esophageal varices in liver cirrhosis.Result:The liver stiffness value,spleen stiffness value,spleen thickness and portal vein inner diameter,FIB4 and APRI in group A,group B and group C were significantly higher than those in group D,the liver stiffness value,spleen stiffness value,spleen thickness and portal vein inner diameter,FIB4 and APRI in group A and group B were significantly higher than those in group C,the liver stiffness value,spleen stiffness value,spleen thickness and portal vein inner diameter,FIB4 and APRI of group A were higher than those of group B,and the differences were statistically significant(P<0.05).Spearman rank correlation analysis showed that liver stiffness value,spleen stiffness value,spleen thickness,portal vein inner diameter,FIB4,APRI were positively correlated with the degree of esophageal varices in liver cirrhosis(P<0.05).Conclusion:The expression of hepatic t

关 键 词：肝瞬时弹性成像指标 脾脏厚度 门静脉内径 血清 纤维化-4指数 天门冬酸氨基转移酶与血小板比率指数 肝硬化 食管静脉曲张 

分 类 号：R575.2[医药卫生—消化系统]