Plasma small-extracellular vesicles enriched in miR-122-5p promote disease aggressiveness in pediatric anaplastic large-cell lymphoma  

作　　者：Carlotta Caterina Damanti Lavinia Ferrone Enrico Gaffo Anna Garbin Anna Tosato Giorgia Contarini Ilaria Gallingani Roberta Angioni Barbara Molon Giulia Borile Elisa Carraro Marta Pillon Federico Scarmozzino Angelo Paolo Dei Tos Marco Pizzi Francesco Ciscato Andrea Rasola Alessandra Biffi Stefania Bortoluzzi Federica Lovisa Lara Mussolin 

机构地区：[1]Maternal and Child Health Department Pediatric Hematology,Oncology and Stem Cell Transplant Center,University of Padua,Padua,Italy [2]Pediatric Research Institute“Cittàdella Speranza”,Padua,Italy [3]Department of Molecular Medicine,University of Padua,Padua,Italy [4]Department of Biomedical Sciences,University of Padua,Padua,Italy [5]General Pathology and Cytopathology Unit,Department of Medicine-DMED,University of Padua,Padua,Italy

出　　处：《Cancer Communications》2023年第5期630-634,共5页癌症通讯（英文）

基　　金：funded by Associazione Italiana per la Ricerca sul Cancro,Milano,Italy(Investigator Grant–IG 2018#21385 to Lara Mussolin),Fondazione Cittàdella Speranza(grant 21/03 to Lara Mussolin)and Fondazione Roche,Roma,Italy(grant“Roche per la ricerca 2018”to Federica Lovisa).

摘　　要：Dear Editor,Anaplastic lymphoma kinase-positive(ALK+)anaplastic large cell lymphoma(ALCL)is an aggressive peripheral Tcell lymphoma representing 10%-15%of pediatric lymphoid neoplasms.The constitutively activated nucleophosmin-ALK(NPM-ALK)fusion protein is the main driver of ALK+ALCL oncogenesis[1].Current clinical protocols can achieve high cure rates,with 75%event-free survival(EFS)at 5 years[2],but the patients’outcome with relapsed/refractory disease still remains poor[3].Liquid biopsy is widely applied for the prognostic and therapeutic stratification of onco-hematological patients.As a non-invasive procedure,it can be used to identify several biomarkers,such as small extracellular vesicles(S-EVs)[4].S-EVs are stable carriers of molecules that mediate genetic exchange between distant cells,alter the microenvironment,facilitate cancer cell progression and promote drug resistance[5].

关 键 词：LYMPHOMA PEDIATRIC NEOPLASMS 

分 类 号：R733.4[医药卫生—肿瘤]