Cynomolgus-rhesus hybrid macaques serve as a platform for imprinting studies  

作　　者：Zongyang Lu Jie Li Yong Lu Ling Li Wei Wang Chenchen Zhang Libing Xu Yanhong Nie Changshan Gao Xinyan Bian Zhen Liu Guang-Zhong Wang Qiang Sun 

机构地区：[1]Institute of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,CAS Key Laboratory of Primate Neurobiology,State Key Laboratory of Neuroscience,Chinese Academy of Sciences,Shanghai 200031,China [2]CAS Key Laboratory of Computational Biology,Shanghai Institute of Nutrition and Health,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200031,China [3]Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Shanghai 201210,China

出　　处：《The Innovation》2023年第3期104-111,共8页创新（英文）

基　　金：supported by the National Key Research and Development Program of China(2022YFF0710901 to Q.S.);the National Natural Science Foundation of China(grants 31825018 and 82021001 toQ.S.;81827901 and 32170567 toG.W.);the ShanghaiMunicipal Science and Technology Major Project(2018SHZDZX05 to Q.S.and Z.Liu);the Biological Resources Program of the Chinese Academy of Sciences(KFJ-BRP-005);the Strategic Priority Research Programof the Chinese Academy of Sciences(XDB32060000 to Q.S.and Z.Liu);the Basic Frontier Scientific Research Program of the Chinese Academy of Sciences From 0 to 1 original innovation project(ZDBS-LY-SM019 to Z.Liu);the China National Postdoctoral Program for Innovative Talents(BX20200350 to Z.Lu).

摘　　要：Genomic imprinting can lead to allele-specific expression(ASE),where one allele is preferentially expressed more than the other.Perturbations in genomic imprinting or ASE genes have been widely observed across various neurological disorders,notably autism spectrum disorder(ASD).In this study,we crossed rhesus cynomolgus monkeys to produce hybrid monkeys and established a framework to evaluate their allele-specific gene expression patterns using the parental genomes as a reference.Our proof-of-concept analysis of the hybrid monkeys identified 353 genes with allele-biased expression in the brain,enabling us to determine the chromosomal locations of ASE clusters.Importantly,we confirmed a significant enrichment of ASE genes associated with neuropsychiatric disorders,including ASD,highlighting the potential of hybrid monkey models in advancing our understanding of genomic imprinting.

关 键 词：IMPRINTING ALLELE CHROMOSOMAL 

分 类 号：Q78[生物学—分子生物学]