抗抑郁剂氟西汀诱导肝损伤的研究现状及策略  

Current research status and strategies of antidepressant fluoxetine induced liver injury

作　　者：张月月(综述)[1] 王君明(审校)[1] Zhang Yueyue;Wang Jun-ming(College of Pharmacy,Henan University of Chinese Medicine,Henan Province,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学药学院,郑州450046

出　　处：《疑难病杂志》2023年第6期669-672,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：国家自然科学基金面上项目(81773928)。

摘　　要：氟西汀是目前广泛应用的抗抑郁药,用药治疗过程中可引起肝炎、皮肤病、性功能障碍、嗜睡、头晕等不良反应,然而目前对其诱导的不良反应的临床前实验研究涉及面较窄,主要集中在对氟西汀诱导的大鼠肝损伤及对其减毒研究方面,致毒机制涉及氧化应激、炎性反应、细胞凋亡等,然而具体机制迄今为止依然不清楚。现对氟西汀诱导肝损伤的致毒机制及其减毒策略的研究进行综述,以提供文献支持和思路启发,助力氟西汀的安全用药进程。Fluoxetine is currently a widely used antidepressant,which can cause adverse reactions such as hepatitis,skin diseases,sexual dysfunction,drowsiness,dizziness,etc.during the treatment process.However,the preclinical experimen⁃tal research on its induced adverse reactions is currently limited.The preclinical experimental research on adverse reactions in⁃duced by fluoxetine mainly focuses on the study of fluoxetine induced liver injury in rats and its reduction in toxicity.The toxicity mechanism involves oxidative stress,inflammatory response,cell apoptosis,etc.However,it is still unclear to date.This article reviews the research on the toxic mechanism and detoxification strategies of fluoxetine induced liver injury,in order to provide literature support and inspiration for the safe use of fluoxetine.

关 键 词：肝损伤 氟西汀 性别差异 致毒机制 减毒研究 

分 类 号：R575[医药卫生—消化系统] R971.43[医药卫生—内科学]