β-七叶皂苷钠联合甘油果糖治疗脑出血的临床效果分析  

Clinical analysis of β-aescinate sodium combined with glycerin fructose in the treatment of cerebral hemorrhage

作　　者：刁正文 徐愈畅 张杰 张华军 李秋霖 陈卉 Zhengwen Diao;Yuchang Xu;Jie Zhang;Huajun Zhang;Qiulin Li;Hui Chen(Department of Neurosurgery,Ya'an City Hospital of Traditional Chinese Medicine,Ya'an 625000,China)

机构地区：[1]雅安市中医医院神经外科,四川雅安625000

出　　处：《中华神经创伤外科电子杂志》2023年第1期32-37,共6页Chinese Journal Of Neurotraumatic Surgery：Electronic Edition

基　　金：四川省医学(青年创新)科研课题(S2009)。

摘　　要：目的:探讨β-七叶皂苷钠联合甘油果糖治疗脑出血的临床效果。方法:前瞻性选取雅安市中医医院神经外科自2018年5月至2020年5月收治的87例脑出血患者作为研究对象,采用随机数字表法将患者随机分为观察组(予以β-七叶皂苷钠联合甘油果糖治疗,43例)和对照组(予以甘油果糖治疗,44例),对比2组患者的美国国立卫生研究院卒中量表(NIHSS)评分、GCS评分、Barthel指数(BI)、NO、基质金属蛋白酶-9(MMP-9)、肿瘤坏死因子-α(TNF-α)、脑血肿量。结果:观察组总有效率(90.70%)高于对照组(63.64%),差异有统计学意义(P<0.05)。重复测量方差分析显示,2组患者的NIHSS评分、GCS评分、BI评分、NO、TNF-α、MMP-9、脑血肿量的时间效应、组间效应、时间与分组的交互作用比较,差异均有统计学意义(P<0.05)。两两比较显示,治疗前,2组患者的NIHSS评分、GCS评分、BI评分、NO、TNF-α、MMP-9及脑血肿量比较,差异均无统计学意义(P>0.05);治疗1、2周后,观察组的NIHSS评分、TNF-α、MMP-9、脑血肿量低于对照组,而GCS评分、BI评分、NO高于对照组,差异均有统计学意义(P<0.05)。结论:β-七叶皂苷钠联合甘油果糖治疗脑出血效果显著,既能改善神经功能,又能降低TNF-α、MMP-9表达。Objective To investigate the clinical effect of β-aescinate sodium combined with glycerin fructose in the treatment of cerebral hemorrhage.MethodsA total of 87 patients with cerebral hemorrhage diagnosed and treated by Neurosurgery Department of Ya'an Hospital of Traditional Chinese Medicine from May 2018 to May 2020 were prospectively selected as research objects. According to the random number table method, they were randomly divided into the observation group (treated with β-aescinate sodium combined with glycerol fructose, n=43) and the control group (treated with glycerol fructose, n=44). The National Institute of Health stroke scale (NIHSS) score, GCS score, Barthel index (BI), NO, matrix metalloproteinase-9 (MMP-9), tumor necrosis factor-α (TNF-α), and cerebral hematoma volume of the two groups were compared.ResultsThe total effective rate of the observation group (90.70%) was higher than that of the control group (63.64%), and the difference was statistically significant (P<0.05). Repeated-measures analysis of variance showed that the comparison of time effect, intergroup effect, time and group interaction of NIHSS score, GCS score, BI score, NO, TNF-α, MMP-9, cerebral hematoma volume between the two groups was statistically significant (P<0.05). Pairwise comparison showed that before treatment, there was no significant difference in NIHSS score, GCS score, BI score, NO, TNF-α, MMP-9, and cerebral hematoma volume between the two groups (P>0.05);after 1 and 2 weeks of treatment, the NIHSS score, TNF-α, MMP-9, and cerebral hematoma volume in the observation group were lower than those in the control group, while the GCS score, BI score, and NO were higher than those in the control group (P<0.05).Conclusionβ-Aescinate sodium combined with glycerol fructose has a significant effect on the treatment of cerebral hemorrhage, which can not only improve nerve function, but also reduce the expression of TNF-α and MMP-9.

关 键 词：Β-七叶皂苷钠 甘油果糖 脑出血 一氧化氮 肿瘤坏死因子-Α 基质金属蛋白酶-9 血肿量 

分 类 号：R743.34[医药卫生—神经病学与精神病学]