骨矿物质密度与结直肠息肉的相关性分析  

Correlation between bone mineral density and colorectal polyps

作　　者：罗小艳 王远志 董小武 於晓平 徐敏敏 Sadman Monsur Jellani 朱馨蓓 路国涛[1] 肖炜明 Luo Xiaoyan;Wang Yuanzhi;Dong Xiaowu;Yu Xiaoping;Xu Minmin;Sadman Monsur Jellani;Zhu Xinbei;Lu Guotao;Xiao Weiming(Department of Gastroenterology Affiliated Hospital of Yangzhou University Yangzhou,225000,China;Health Management Centre Affiliated Hospital of Yangzhou University Yangzhou,225000,China;Dalian Medical University Dalian,116044,China)

机构地区：[1]扬州大学附属医院消化内科,扬州225000 [2]扬州大学附属医院健康管理中心,扬州225000 [3]大连医科大学,大连116044

出　　处：《中国医药》2023年第6期864-867,共4页China Medicine

基　　金：国家自然科学基金(81873866)。

摘　　要：目的探讨骨矿物质密度(BMD)与结直肠息肉的相关性。方法回顾性收集扬州大学附属医院健康管理中心2016年1月至2021年12月体检人群的信息。记录受试者一般资料、实验室指标、BMD及结直肠镜检查结果。根据是否有结直肠息肉,将患者分为息肉组和非息肉组。比较2组上述指标差异,进一步进行性别分类比较。采用二分类Logistic回归模型分析不同性别人群发生结直肠息肉的危险因素。结果本研究共纳入406例受试者,其中息肉组174例、非息肉组232例。息肉组男性、年龄≥50岁、高血压病、糖尿病、BMD降低比例及年龄、收缩压、舒张压、总胆固醇、低密度脂蛋白、空腹血糖、血尿酸水平均高于非息肉组,差异均有统计学意义(均P<0.05)。二分类Logistic回归分析结果显示,年龄≥50岁(比值比=1.695,95%置信区间:1.032~2.783,P=0.037)、高血压病(比值比=1.839,95%置信区间:1.061~3.189,P=0.030)、糖尿病(比值比=1.970,95%置信区间:1.074~3.615,P=0.028)为男性发生结直肠息肉的独立危险因素,BMD降低(比值比=2.990,95%置信区间:1.174~7.619,P=0.022)为女性发生结直肠息肉的独立危险因素。将女性结直肠息肉患者分为BMD降低组(27例)和BMD正常组(11例),2组息肉数量、直径、位置比较,差异均无统计学意义(均P>0.05)。结论BMD降低是女性发生结直肠息肉的独立危险因素,而在男性人群中未发现相关性。Objective To investigate the correlation between bone mineral density(BMD)and colorectal polyps.Methods From January 2016 to December 2021,the data of people undergoing health check-up were retrospectively collected from Health Management Center,Affiliated Hospital of Yangzhou University.The general information,laboratory indicators,BMD and results of colorectal microscopy were recorded.The subjects were divided into polyp group and non-polyp group according to the presence or absence of colorectal polyps.Differences of above indexes were compared between the two groups,and further gender stratified comparisons were performed.Binomial Logistic regression model was used to analyze the risk factors of colorectal polyps in different gender groups.Results Totally 406 subjects were enrolled,with 174 cases in polyp group and 232 cases in non-polyp group.The rates of men,age≥50 years,hypertension,diabetes mellitus and BMD reducing,and levels of age,systolic blood pressure,diastolic blood pressure,total cholesterol,low-density lipoprotein,fasting plasma glucose and blood uric acid in polyp group were higher than those in non-polyp group(all P<0.05).Binomial Logistic regression analysis showed that age≥50 years[odds ratio(OR)=1.695,95%confidence interval(CI):1.032-2.783,P=0.037],hypertension(OR=1.839,95%CI:1.061-3.189,P=0.030)and diabetes mellitus(OR=1.970,95%CI:1.074-3.615,P=0.028)were independent risk factors of colorectal polyps for male,and BMD reducing(OR=2.990,95%CI:1.174-7.619,P=0.022)was an independent risk factor for female.The female with colorectal polyps were divided into BMD reducing group(27 cases)and BMD normal group(11 cases),and there were no significant differences in polyp number,size and site(all P>0.05).Conclusion BMD reducing is an independent risk factor of colorectal polyps for female,while there is no coloration for male.

关 键 词：结直肠息肉 骨矿物质密度 危险因素 

分 类 号：R574.6[医药卫生—消化系统]