精神分裂症患者眼底结构和功能改变研究进展  

Research progress of structural and functional changes in the fundus in patients with schizophrenia

作　　者：王艳 李聪 任赟 赵翰鹏 杜振超 何雪 江建荣 刘磊[4] 杨小红 Wang Yan;Li Cong;Ren Yun;Zhao Hanpeng;Du Zhenchao;He Xue;Jiang Jianrong;Liu Lei;Yang Xiaohong(School of Medicine,South China University of Technology,Guangzhou 510006,China;Medical College of Shantou University,Shantou 515063,China;Southern Medical University,Guangzhou 510515,China;Guangdong Eye Institute,Guangdong Provincial People′s Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510080,China)

机构地区：[1]华南理工大学医学院,广州510006 [2]汕头大学医学院,汕头515063 [3]南方医科大学,广州510515 [4]广东省眼病防治研究所、南方医科大学附属广东省人民医院(广东省医学科学院),广州510080

出　　处：《中华精神科杂志》2023年第3期193-198,共6页Chinese Journal of Psychiatry

基　　金：国家自然科学基金(面上项目82271125);广东省心血管疾病专项研究项目(2020XXG007)。

摘　　要：既往精神分裂症的诊断多依赖于患者主观症状和医生的临床经验,主观性较强,因此亟需客观且重复性好的评估工具进行辅助诊断。目前已知大脑结构和功能的改变与精神分裂症发生发展密切相关,而视网膜是中枢神经系统的一部分,与大脑在形态学和生理学上高度相似,并可通过无创便捷的眼底检查对其改变予以评估。已有研究利用光学相干断层扫描、眼底彩照、光学相干断层扫描血管成像和视网膜电图发现精神分裂症患者的眼底结构和功能的重要改变,但尚缺乏对相关研究的归纳概括。本文中对该领域的研究结果进行总结和讨论,旨在探讨眼底改变在精神分裂症诊疗中的应用价值。Previously,the diagnosis of schizophrenia was empirical since it relied on the patient′s subjective symptoms and the practitioner′s clinical experience.There is an urgent need for objective and reproducible assessment tools to aid its diagnosis.Changes in brain structure and function are closely related to the development of schizophrenia.The retina,a part of the central nervous system,is highly similar to the brain morphologically and neurophysiologically and can be assessed by a non-invasive and convenient fundus examination.There have been studies using optical coherence tomography,fundus photography,optical coherence tomography angiography,and electroretinography to identify significant changes in the structure and function of the fundus in patients with schizophrenia.However,there is still a lack of generalization in these studies.This article summarises and discusses the findings in this area and presents a vision for future studies to explore the application value of fundus in the management of schizophrenia.

关 键 词：精神分裂症 体层摄影术 光学相干 视网膜电描记术 眼底彩照 光学相干断层扫描血管成像 

分 类 号：R749.3[医药卫生—神经病学与精神病学]