2010-2020年山西省围产儿先天性唇腭裂的发生率及变化趋势研究  

Incidence of congenital cleft lip and cleft palate in Shanxi province and its trend from 2010 to 2020

作　　者：李泽红 李玉凤[2] 陈东方 Li Zehong;Li Yufeng;Chen Dongfang(Department of Information,Shanxi Provincial Children′s Hospital,Shanxi Provincial Maternal and Child Health Hospital,Taiyuan 030013,China;Department of Development Pediatrics,Shanxi Provincial Children′s Hospital,Shanxi Provincial Maternal and Child Health Hospital,Taiyuan 030013,China)

机构地区：[1]山西省儿童医院、山西省妇幼保健院信息资料科,太原030013 [2]山西省儿童医院、山西省妇幼保健院发育儿科,太原030013

出　　处：《中华全科医师杂志》2023年第6期592-597,共6页Chinese Journal of General Practitioners

摘　　要：目的了解2010—2020年山西省围产儿先天性唇腭裂发生率的变化趋势。方法本研究为横断面研究。对2010—2020年在山西省医院监测系统监测到的围产儿临床资料进行回顾性分析,分析唇裂、腭裂、唇裂合并腭裂及总体唇腭裂患者的分布特征、发生趋势及产前诊断相关特征。结果2010—2020年山西省累计围产儿数843457例,总唇裂1264例,发生率14.99/万,其中腭裂199例,占15.74%,发生率为2.36/万;唇裂358例,占28.33%,发生率4.24/万;唇裂合并腭裂707例,占55.93%,发生率8.38/万。11年间总唇裂的发生率有降低趋势(χ_(趋势)^(2)=104.04,P<0.001)。乡村围产儿总唇裂发生率为19.13/万,大于城市的11.50/万,差异有统计学意义(χ^(2)=81.29,P<0.001)。男围产儿总唇裂发生率为16.41/万,高于女围产儿的13.41/万,差异有统计学意义(χ^(2)=90.59,P<0.001)。孕母各年龄组间唇腭裂患儿的发生率差异有统计学意义(χ^(2)=58.40,P<0.001),年龄<20岁(21.66/万)和20~<25岁(21.06/万)的两个组发生率高于其他组。总唇裂的产前诊断比例为27.85%(352/1264),呈增高趋势(χ_(趋势)^(2)=6.96,P=0.008)。结论2010—2020年山西省先天性唇腭裂发生率呈下降趋势,产前诊断率呈增高趋势。Objective To analyze the incidence of congenital cleft lip and cleft palate in Shanxi province and its trend from 2010 to 2020.Methods The clinical data of perinatal infants from 2010 to 2020 were collected from Shanxi Provincial Hospital Monitoring System,and the distribution,prenatal diagnosis,the incidence of cleft lip,cleft palate,and the trend were analyzed.Results From 2010 to 2020,among 843457 prenatal infants in Shanxi province,there were 1264 cases of cleft lip and/or cleft palate with an overall incidence rate of 14.99/10^(4).Among them 199 cases were cleft palate(15.74%)with an incidence rate of 2.36/10^(4);358 cases were cleft lip(28.33%)with an incidence rate of 4.24/10^(4);707 cases were cleft lip with cleft palate(55.93%)with an incidence rate of 8.38/10^(4).The overall incidence of cleft lip and/or cleft palate was significantly decreased from 2010 to 2020(χ^(2)=104.04,P<0.001).The incidence of cleft lip in rural area was higher than that in urban areas(19.13/10^(4)vs.11.50/10^(4),χ^(2)=81.29,P<0.001);the incidence in male infants was higher than that in female infants(16.41/10^(4) vs.13.41/10^(4),χ^(2)=90.59,P<0.001).There were significant differences in the incidence of cleft lip and cleft palate among different maternal ages(χ^(2)=58.40,P<0.001);the incidence in maternal age<20 years(21.66/10^(4))and 20-<25 years(21.06/10^(4))was higher than that of other groups.The proportion of prenatal diagnosis of total cleft lip was 27.85%(352/1264),which showed an increasing trend(χ^(2)=6.96,P=0.008).Conclusion From 2010 to 2020,the incidence of congenital cleft lip and palate in Shanxi province shows a decreasing trend,while the prenatal diagnosis rate shows an increasing trend.

关 键 词：唇裂 腭裂 医院监测 变化趋势 产前诊断 

分 类 号：R714.53[医药卫生—妇产科学]