胃癌患者凝血功能相关指标检测及其水平变化的临床意义分析  

Clinical significance of detection of coagulation related indexes and their changes in patients with gastric cancer

作　　者：刘征 Liu Zheng(Changsha Hospital of Traditional Chinese Medicine,Changsha,Hunan 410001,China)

机构地区：[1]长沙市中医医院,湖南长沙410001

出　　处：《首都食品与医药》2023年第11期86-89,共4页Capital Food Medicine

摘　　要：目的探讨胃癌患者凝血功能相关指标检测及其水平变化的临床意义.方法选取2018年7月-2022年5月在长沙市中医医院接受诊治的100例胃癌患者设为观察组,另同期于该院接受健康体检的健康人员中选取100例设为对照组,两组均行凝血功能相关指标检测,包括血浆D二聚体(D-D)、血小板计数(PLT)、纤维蛋白原(FIB)、血浆凝血酶原时间(PT)、活化部分凝血酶时间(APTT)、凝血酶时间(TT).对比分析两组的上述指标水平,并分析观察组不同TNM分期、分化程度、有无转移患者的上述凝血功能指标水平.结果观察组的D-D、PLT、FIB、PT水平比对照组高(P<0.05),两组的APTT、TT水平比较,差异无统计学意义(P>0.05);Ⅳ期患者的D-D、PLT、FIB水平明显比Ⅲ期、Ⅱ期、Ⅰ期患者高,且Ⅲ期高于Ⅱ期、Ⅰ期,Ⅱ期高于Ⅰ期(P<0.05),各分期患者的PT、APTT、TT水平对比,差异无统计学意义(P>0.05);低分化组的D-D、PLT、FIB、PT、APTT、TT水平均比高-中分化组高(P<0.05);出现转移患者的D-D、PLT、FIB比无转移者高(P<0.05),二者的PT、APTT、TT水平对比,差异无统计学意义(P>0.05);D-D、PLT、FIB与胃癌患者TNM分期、分化程度、转移情况呈明显的正相关关系.结论胃癌患者存在明显的凝血功能异常,且异常程度与肿瘤分期、分化程度、转移情况紧密关联,临床上可积极将此类指标应用于胃癌诊治中.Objective To investigate the clinical significance of the detection of blood coagulation related indexes and their changes in patients with gastric cancer.Methods 100 cases of patients with gastric cancer who were diagnosed and treated in our hospital from July 2018 to May 2022 were selected as the observation group,100 cases of healthy people who were received physical examination at the same time in our hospital were selected as the control group,h te indexes related to coagulation function were detected in boht groups,including plasma D-dimer(D-D),platelet count(PLT),fibrinogen(FIB),plasma prothrombin time(PT),activated partial thrombin time(APTT),thrombin time(TT),the levels of the above indicatorsw ere comparde and analyzed in the two groups,and the levels o tfhe above coagulation function indicators in patients with different TNMs tages,differentiation degrees,and node metastasis in the obesrvation group were analyzed.Results In the observation group,the levels of D-D,PLT,FIB and PT wree higher than the control groupP(<0.05),there was no significant difference in the levels of APTT and TT between the two groups(P>0.05).The levels of D-D,PLT and FIB in stage IV patients were significantly higher than those in stage III,IIa nd I patients,and stage III patients were higher than thosen i stage II and I patients,and stage II patients were higher than those in stage I patients P(<0.05),there was no significant difference in the levels of PT,APTT and TT among patients in different stages P(>0.05).The levels of D-D,PLT,FIB,PT,APTT and TT in the poorly differentiated group were higher than those in the highly moderately differentiated group(P<0.05).The D-D,PLT and FIB levels of the patients with metastasis were higher than those without metastasis(P<0.05),there was no significant difference in the levels of PT,APTT and TT between the two groups P(>0.05).The levels of D-D,PLT,FIB were positively correlatedw ith TNM stage,differentiation and metastasis o f gastric cancer patients.Conclusion Patients with gastric cance

关 键 词：胃癌 凝血功能 肿瘤分期 分化程度 转移 

分 类 号：R735.2[医药卫生—肿瘤]