胰高血糖素样肽-2改善溃疡性结肠炎的研究进展  

Research progress of glucagon like peptide-2 and ulcerative colitis

作　　者：岳娜 王韶轩[2] YUE Na;WANG Shaoxuan(Shandong First Medical University&Shandong Academy of Medical Sciences,Jinan 250117,China;Department of gastroenterology,Jining First People's Hospital,Jining 272011,China)

机构地区：[1]山东第一医科大学(山东省医学科学院)研究生部,山东济南250117 [2]济宁市第一人民医院消化内科,山东济宁272011

出　　处：《山东第一医科大学（山东省医学科学院）学报》2023年第5期392-395,共4页Journal of Shandong First Medical University ＆ Shandong Academy of Medical Sciences

基　　金：济宁市重点研发计划(2021YXNS017)。

摘　　要：溃疡性结肠炎(ulcerative colitis,UC)是一种影响结肠、直肠的慢性特发性炎症性疾病,近年来随着UC发病率逐渐增高,有关UC治疗的研究越来越受到重视。胰高血糖素样肽-2(glucagon like peptide-2,GLP-2)是一种在营养摄入的反应中释放的胃肠激素。GLP-2与GLP-2受体(glucagon like peptide-2 receptor,GLP-2R)结合后具有促进营养吸收、降低炎症反应、改善肠道血流灌注、促进肠黏膜增殖,改善肠道屏障功能等作用。GLP-2对肠道的有益作用,为UC的治疗提供了新方法、新思路。Ulcerative colitis(UC)is a chronic idiopathic inflammatory disease that affects the colon and rectum.In recent years,with the gradual increase of the incidence rate of UC,more and more attention has been paid to the research on the treatment of UC.Glucagon like peptide-2(GLP-2)is a gastrointestinal hormone released in response to nutrient intake.The combination of GLP-2 and GLP-2 receptor(GLP-2R)can promote nutrient absorption,reduce inflammation,improve intestinal blood flow perfusion,promote intestinal mucosa proliferation,and improve intestinal barrier function.In view of its beneficial effect on the intestinal tract,GLP-2 provides a new method and new idea for the treatment of UC.

关 键 词：胰高血糖素样肽-2 肠道作用 溃疡性结肠炎 机制 

分 类 号：R574.62[医药卫生—消化系统]