调神针刺治疗阿尔茨海默病的效果及对患者血清超氧化物歧化酶水平的影响  

Effect of regulating mind acupuncture the treatment of Alzheimer′s disease antits influence on serum superoxide dismutase level

作　　者：徐利飞 董秋平 李慧 XU Lifei;DONG Qiuping;LI Hui(Department of Encephalopathy,Zhenjiang Hospital Affiliated to Nanjing University of Chinese Medicine(Zhenjiang Hospital of Traditional Chinese Medicine),Jiangsu Province,Zhenjiang 212000,China;Department of Rehabilitation,Zhenjiang Hospital Affiliated to Nanjing University of Chinese Medicine(Zhenjiang Hospital of Traditional Chinese Medicine),Jiangsu Province,Zhenjiang 212000,China;Department of Acupuncture and Moxibustion,Zhenjiang Hospital Affiliated to Nanjing University of Chinese Medicine(Zhenjiang Hospital of Traditional Chinese Medicine),Jiangsu Province,Zhenjiang 212000,China)

机构地区：[1]南京中医药大学镇江附属医院(镇江市中医院)脑病科,江苏镇江212000 [2]南京中医药大学镇江附属医院(镇江市中医院)康复科,江苏镇江212000 [3]南京中医药大学镇江附属医院(镇江市中医院)针灸科,江苏镇江212000

出　　处：《中国当代医药》2023年第16期92-95,共4页China Modern Medicine

基　　金：江苏省镇江市社会发展指导性科技计划项目(FZ2020061)。

摘　　要：目的观察调神针刺法治疗阿尔茨海默病(AD)的临床效果,以及对患者血清超氧化物歧化酶(SOD)水平的影响。方法选取2020年5月至2022年10月镇江市中医院收治的80例AD患者作为研究对象,采用随机数字表法分为观察组(40例)和对照组(40例)。观察组采用调神针刺法治疗,对照组给予安慰剂口服。比较两组患者治疗前后简易智力状态量表(MMSE)和日常生活能力量表(ADL)的评分情况,以及患者血清SOD水平变化。结果治疗后观察组MMSE和ADL评分均高于治疗前,差异有统计学意义(P<0.05),对照组治疗前后比较,差异无统计学意义(P>0.05);治疗后观察组MMSE和ADL评分均高于对照组,差异有统计学意义(P<0.05)。治疗后观察组血清SOD水平高于治疗前,差异有统计学意义(P<0.05),对照组治疗前后比较,差异无统计学意义(P>0.05);治疗后观察组血清SOD水平高于对照组,差异有统计学意义(P<0.05)。结论调神针刺法可通过调节机体的氧化应激水平从而改善AD患者的智能水平及日常生活能力,这可能是针刺治疗AD的机理之一,本研究丰富了临床针刺治疗AD的理论依据,且无明显不良反应,值得临床推广应用。Objective To observe the effect of mind-regulating acupuncture on the bed of Alzheimer's disease(AD)and its effect on the level of serum superoxide dismutase(SOD)in patients.Methods Eighty cases of AD patients admitted to Zhenjiang Hospital of Traditional Chinese Medicine from May 2020 to October 2022 were selected as the research objects,and they were divided into observation group(40 cases)and control group(40 cases)by random number table method.The observation group was treated with acupuncture and control group was given placebo orally.The scores of mini-mental state examination(MMSE)and activity daily living scale(ADL)before and after treatment were compared between the two groups,as well as the changes of serum SOD level.Results After treatment,MMSE and ADL scores in the observation group were higher than those before treatment,with statistical significance(P<0.05),while there was no statistical significance in the control group before and after treatment(P>0.05).After treatment,MMSE and ADL scores in observation group were higher than those in control group,and the difference was statistically significant(P<0.05).After treatment,the serum SOD level in the observation group was higher than that before treatment,and the difference was statistically significant(P<0.05),while there was no statistical significance in the control group before and after treatment(P>0.05).After treatment,the serum SOD level in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).Conclusion Regulating mind acupuncture can improve the intelligence level and ability of daily life of AD patients by regulating the level of oxidative stress in the body,which may be one of the mechanisms of acupuncture treatment of AD.This study enriches the theoretical basis of clinical acupuncture treatment of AD,and has no obvious adverse reactions,which is worthy of clinical promotion and application.

关 键 词：调神针刺 阿尔茨海默病 临床效果 血清超氧化物歧化酶 

分 类 号：R741[医药卫生—神经病学与精神病学]