食管感觉性受体信号通路在食管高敏感发生中的作用  

Role of Esophageal Sensory Receptor Pathways in Development of Esophageal Hypersensitivity

作　　者：吴白馨 沈磊[1] 余晓云[2] WU Baixin;SHEN Lei;YU Xiaoyun(Department of Gastroenterology,Renmin Hospital of Wuhan University,Wuhan 430060;Department of Gastroenterology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan)

机构地区：[1]武汉大学人民医院消化内科,430060 [2]华中科技大学同济医学院附属协和医院消化内科

出　　处：《胃肠病学》2022年第4期250-253,共4页Chinese Journal of Gastroenterology

基　　金：国家自然科学基金(82070555)。

摘　　要：胃食管反流病(GERD)是一种常见的消化道疾病,烧心和反酸是GERD的典型症状。近年诸多研究显示食管高敏感是烧心症状发生、发展的重要病理生理机制,瞬时受体电位香草酸亚型1(TRPV1)、前列腺素E2受体1(EP1)、蛋白酶活化受体2(PAR2)、瞬时受体电位M8(TRPM8)在食管高敏感的发生机制中起关键作用。本文就食管感觉性受体信号通路在食管高敏感发生中的作用作一综述。Gastroesophageal reflux disease(GERD)is a common digestive disease characterized by heartburn and acid reflux.In recent years,many studies have shown that esophageal hypersensitivity is an important pathophysiological mechanism involved in the occurrence and development of heartburn.Esophageal sensory receptors including transient receptor potential vanilloid 1(TRPV1),prostaglandin E2 receptor 1(EP1),protease⁃activated receptor 2(PAR2)and transient receptor potential melastatin 8(TRPM8)play a key role in the pathogenesis of esophageal hypersensitivity.This article reviewed the role of esophageal sensory receptor pathways in the development of esophageal hypersensitivity.

关 键 词：食管高敏感 食管感觉性受体 胃食管反流病 烧心 

分 类 号：R571[医药卫生—消化系统]