CT引导下经皮穿刺活检同步微波消融治疗特发性肺间质纤维化合并Ⅰ期非小细胞肺癌  

CT-guided synchronous percutaneous biopsy and microwave ablation for treating stageⅠnon-small cell lung cancer in patients with idiopathic pulmonary fibrosis

作　　者：李彬 别志欣[1] 李元明[1] 郭润碛 王承恩 李晓光[1] LI Bin;BIE Zhixin;LI Yuanming;GUO Runqi;WANG Cheng'en;LI Xiaoguang(Minimally Invasive Tumor Therapies Center,Beijing Hospital,National Center of Gerontology,Institute of Geriatric Medicine,Chinese Academy of Medical Sciences,Beijing 100730,China)

机构地区：[1]北京医院肿瘤微创治疗中心、国家老年医学中心、中国医学科学院老年医学研究院,北京100730

出　　处：《中国介入影像与治疗学》2023年第6期325-329,共5页Chinese Journal of Interventional Imaging and Therapy

摘　　要：目的观察CT引导下经皮穿刺活检同步微波消融(MWA)治疗特发性肺间质纤维化(IPF)合并Ⅰ期非小细胞肺癌(NSCLC)的价值。方法纳入16例接受CT引导下经皮穿刺活检同步MWA治疗的IPF合并Ⅰ期NSCLC患者,观察其技术成功率、治疗相关不良反应及并发症、有效率及患者生存期,评价穿刺活检同步MWA治疗的效果。结果穿刺活检同步MWA治疗Ⅰ期NSCLC技术成功率100%。术后6个月治疗有效率81.25%(13/16),术后12个月治疗有效率56.25%(9/16)。10例发生治疗相关并发症,包括气胸5例、咯血3例、肺部感染2例、胸腔积液2例及皮下气肿1例;13例出现治疗相关不良反应,其中疼痛10例、低热3例。随访5~36个月,中位随访时间15.5个月;患者中位生存期23个月。结论CT引导下经皮穿刺活检同步MWA治疗IPF合并Ⅰ期NSCLC安全、有效。Objective To observe the value of CT-guided synchronous percutaneous biopsy and microwave ablation(MWA)for treating idiopathic pulmonary fibrosis(IPF)complicated with stageⅠnon-small cell lung cancer(NSCLC).Methods Sixteen IPF patients complicated with stageⅠNSCLC who underwent CT-guided synchronous percutaneous biopsy and MWA were enrolled.The technical success rate,adverse reaction,related complications,effective rate and patient survival time were observed,and the effect of synchronous percutaneous biopsy and MWA were evaluated.Results The success rate of synchronous percutaneous biopsy and MWA of stageⅠNSCLC was 100%.The effective rate of treatment was 81.25%(13/16)at 6 months and 56.25%(9/16)at 12 months after operation.Treatment-related complications were observed in 10 cases,including 5 cases of pneumothorax,3 cases of hemoptysis,2 cases of pulmonary infection,2 cases of pleural effusion and 1 case of subcutaneous emphysema.Treatment-related adverse reactions were noticed in 13 cases,including 10 cases of pain and 3 cases of low fever.The patients were followed-up for 5—36 months,with a median follow-up time of 15.5 months,and the patient median survival time was 23 months.Conclusion CT-guided synchronous percutaneous biopsy and MWA was safe and effective for treating stageⅠNSCLC in patients with IPF.

关 键 词：癌 非小细胞肺 肺纤维化 消融技术 活组织检查 体层摄影术 X线计算机 

分 类 号：R734.2[医药卫生—肿瘤] R815[医药卫生—临床医学]