血管性帕金森综合征的生活质量影响因素分析  

Influencing factors of quality of life in patients of vascular parkinsonism

作　　者：詹翠京 聂坤[1] 高玉元[1] 李彦颐 邱轶慧 马桂贤 张玉虎[1] 王丽娟[1] Zhan Cuijing;Nie Kun;Gao Yuyuan;Li Yanyi;Qiu Yihui;Ma Guixian;Zhang Yuhu;Wang Lijuan(Department of Neurology,Guangdong Provincial People's Hospital(Guangdong Academy of Medical Sciences),Southern Medical University,Guangzhou 510000,Guangdong Province,China)

机构地区：[1]南方医科大学附属广东省人民医院(广东省医学科学院)神经科,广州510000

出　　处：《中华老年心脑血管病杂志》2023年第5期493-496,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：国家重点研发计划项目(2017YFC131200);国家自然科学基金(81974195,82071419,82101377);广东省科技计划项目(2020A0505140006);广州市神经退行性疾病诊治研究重点实验室(202201000005);广东省医学科研基金(A2021308)。

摘　　要：目的探讨血管性帕金森综合征(VP)的临床特征对生活质量的影响。方法收集2021年6月至2022年7月在广东省人民医院神经科门诊就诊及住院的VP患者60例为VP组及帕金森病(PD)患者60例为PD组,比较2组临床特征及生活质量差异。采用多元线性回归分析影响VP患者生活质量的危险因素。结果VP组高脂血症(31.7%vs 15.0%)、吸烟(46.7%vs 23.3%)、饮酒(26.7%vs 11.7%)、跌倒比例(58.3%vs 23.3%)明显高于PD组,差异有统计学意义(P<0.05,P<0.01)。VP组国际运动障碍病学会-统一帕金森病评定量表Ⅲ(MDS-UPDRS-Ⅲ)评分、Hoeh-Yahr分级、汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分、39项PD问卷(PDQ-39)评分明显高于PD组(P<0.05,P<0.01),简易智能状态检查量表(MMSE)评分明显低于PD组(P<0.01)。多元线性回归分析显示,HAMD评分、MDS-UPDRS-Ⅲ评分、MMSE评分、跌倒是影响VP组患者生活质量的危险因素(P<0.05,P<0.01)。结论相较于PD患者,VP患者血管危险因素更常见且运动症状、非运动症状更严重,生活质量明显下降。抑郁、认知功能下降、运动功能下降、跌倒会降低VP患者生活质量。Objectives To delineate the clinical features of VP and determine their effects on quality of life in patients.Methods A total of 60 VP patients and another 60 patients suffering from idiopathic PD admitted to our inpatient and outpatient department from June 2021 to July 2022 were recruited in this study.Differences in clinical characteristics and quality of life were collected and compared between the 2 groups.Multivariate linear regression analysis was used to explore the risk factors influencing quality of life in VP patients.Results The VP patients had significantly larger proportions of hyperlipidemia(31.7%vs 15.0%),history of smoking(46.7%vs 23.3%),alcoholic drinking(26.7%vs 11.7%)and falling(58.3%vs 23.3%)when compared with the PD patients(P<0.05,P<0.01).The scores of MDS-UPDRS-Ⅲ,HAMD Scale,HAMA Scale,PDQ-39,H-Y stage,and ratio of falling history were obviously higher,but the score of MMSE was notably lower in the VP patients than the PD patients(P<0.05,P<0.01).Multivariate linear regression analysis showed that HAMD,MDS-UPDRS-Ⅲand MMSE scores,and falling were the risk factors influencing quality of life in the VP patients(P<0.05,P<0.01).Conclusion Compared with PD patients,VP patients are common with more vascular risk factors,more severe motor and non-motor symptoms,and worse quality of life.Depression,cognitive impairment,declined motor symptoms,and falling can reduce the quality of life in VP patients.

关 键 词：帕金森障碍 生活质量 回归分析 数据相关性 

分 类 号：R742.5[医药卫生—神经病学与精神病学]