维生素D_(3)及其羟基衍生物合成研究进展  

Progress in Synthesis of Vitamin D_(3) and Its Hydroxyl Derivatives

作　　者：刘绍鹏[1,2] 姜艳 宋凯 耿君霞[4] 王伟 康尚渝 康惠鹏 张成明 Liu Shaopeng;Jiang Yan;Song Kai;Geng Junxia;Wang Wei;Kang Shangyu;Kang Huipeng;Zhang Chengming(School of Medicine and Food,Xuzhou Vocational College of Bioengineering,Xuzhou 221006,China;Xuzhou Biopharmaceutical and Waste Comprehensive Engineering Technology Research Center,Xuzhou 221006,China;ZJ Bondi Labs(Beijing)Intelligent Technologies Co.,Ltd.,Beijing 101318,China;Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang 050000,China;Xuzhou Mine Hospital,Xuzhou 221006,China;Kunming Medical University Haiyuan College,Kunming 650106,China)

机构地区：[1]徐州生物工程职业技术学院药品食品学院,江苏徐州221006 [2]徐州市生物制药与废弃物综合利用工程中心,江苏徐州221006 [3]中检邦迪(北京)智能科技有限公司,北京101318 [4]石家庄市妇幼保健院,河北石家庄050000 [5]徐州市矿山医院,江苏徐州221006 [6]昆明医科大学海源学院,云南昆明650106

出　　处：《山东化工》2023年第7期73-82,共10页Shandong Chemical Industry

基　　金：江苏省高等职业院校专业带头人高端研修资助项目(2020TDFX008);维生素D受体改善帕金森小鼠多巴胺能神经元损伤的分子机制研究(KC22014)。

摘　　要：维生素D是一种脂溶性维生素,在调节人体钙、磷代谢,促进骨骼发育方面起重要作用。此外,维生素D与高血压、2型糖尿病、免疫调节、心血管疾病、各种癌症等疾病密切相关。随着VD生理活性不断被发现,市场对维生素D及其衍生物的需求也不断增长,目前维生素D及其衍生物的生产已逐渐无法满足市场需要。本文综述了7-脱氢胆固醇、维生素D_(3)、1α-羟基维生素D_(3)、25-羟基维生素D_(3)和1,25-二羟基维生素D_(3)的合成进展,以期为该领域的研究者改进现有生产工艺和建立新的生产工艺提供借鉴。Vitamin D(VD)is a fat-soluble vitamin,which plays an important role in regulating calcium and phosphorus metabolism and promoting bone development.In addition,VD is closely related to hypertension,type 2 diabetes,immune regulation,cardiovascular disease,various cancers and other diseases.With the discovery of the physiological activity of VD,the market demand for VD and its derivatives is also growing.At present,the production of VD and its derivatives has gradually failed to meet the market demand.This article reviewed the synthesis progress of 7-dehydrocholesterol,vitamin D_(3),1α-hydroxyvitamin D_(3),25 hydroxyvitamin D_(3) and 1,25 dihydroxyvitamin D_(3) to provide reference for researchers in this field to improve the existed production process and establish new production process.

关 键 词：7-脱氢胆固醇 维生素D 1α-羟基维生素D_(3)、25-羟基维生素D_(3) 1 25-二羟基维生素D_(3) 化学合成 甾体化合物 

分 类 号：O629.4[理学—有机化学]