探讨双层探测器光谱CT在评价结直肠癌化疗短期疗效中的应用价值  

To Investigate the Application Value of Double Detector Spectral CT in Evaluating the Short-term Efficacy of Chemotherapy for Colorectal Adenocarcinoma

作　　者：姜允山 赖发明 林蓉 谢丽卿 Jiang Yunshan;Lai Faming;Lin Rong;Xie Liqing(Department of Medical oncology,the First Hospital of Longyan of Fujian Medical University,Longyan,Fujian 364000;Department of Radiology,the First Hospital of Longyan of Fujian Medical University,Longyan,Fujian 364000)

机构地区：[1]福建医科大学附属龙岩第一医院肿瘤内科,福建龙岩364000 [2]福建医科大学附属龙岩第一医院放射科,福建龙岩364000

出　　处：《现代医用影像学》2023年第5期837-841,共5页Modern Medical Imageology

基　　金：龙岩市科技计划项目,2020LYF17039。

摘　　要：目的:探讨光谱CT多参数分析在结直肠癌化疗短期疗效评价中的应用价值。方法:收集我院34例经活检病理确诊的不可手术的Ⅲ~Ⅳ期结直肠癌短期化疗前后的光谱CT增强扫描参数,并根据RECIST 1.1标准分为有效组(CR+PR)和无效组(SD+PD)。比较两组间化疗前后动脉期、静脉期的标准化碘浓度(NIC)、能谱曲线斜率K((40-90keV))差异。结果:有效组25例(CR, PR),无效组9例(SD, PD)。治疗前,有效组与无效组的各期NIC及K((40-90keV))指标比较,差异均无统计学意义(P> 0.05)。治疗后,有效组上述指标均低于治疗前,差异有统计学意义(P<0.05);无效组上述指标略低于治疗前,差异无统计学意义(P> 0.05);且有效组的NIC及K((40-90keV))治疗前后差值大于无效组,差异有统计学意义(P<0.05)。结论:光谱CT参数NIC、K((40-90keV))及治疗前后差值可作为结直肠癌短期化疗后疗效的评价指标,可协助临床更为准确的评价肿瘤对化疗药物的敏感性,对于指导临床用药具有较高的应用价值。Purpose:To investigatetheapplication valueof IQon dual-layer spectral detector CT multi-parameter analysis in the short-term efficacy of chemotherapy for colorectal adenocarcinoma.Methods:34 patients in the First Hospital of Longyan of Fujian Medical University from October 2020 to April 2022 with II~IV colorectal adenocarcinoma diagnosed by bioptic pathology were enrolled in this study,spectral CT parameters before and after the short-term efficacy of chemotherapy were retrospectively analyzed.Divided into effective group(CR+PR)and ineffective group(SD+PD)according to RECIST 1.1 criteria.The normalized iodine concentra-tion(NIC)and energy spectrum curve slope K(40-90keV)were compared between the two groups before and after chemotherapy.Results:25 patients in effective group(CR,PR)and 9 patients in invalid group(SD,PD).Before treatment,there were no significant dfferences(P>0.05)in NIC and K(40-90keV)between the effective group and the ineffective group;After treatment,the indexes in effective group were lower than before treatment,with statistical significance(P<0.05);the indexes in ineffective group were Slightly lower than before treatment,with no significant difference(P>0.05);And the NIC and K(40-90keV)intheeffective group decreased more than that in the invalid group,with statistical significance(P<O.05).Conclusion:Spectral CT parameters NIC,K(40-90keV)and their decreased values can be used as evaluation indicators for the efficacy of short-term chemotherapy in colorectal cancer,can assist more accurate clinical evaluation of tumor sensitivity to chemotherapeutic drugs,and have high application value for guiding clinical drugs.

关 键 词：光谱CT 结直肠癌 化疗 临床疗效 

分 类 号：R735.34[医药卫生—肿瘤]