“One-for-All”approach:a black technology for nanomedicine development?  

作　　者：Jiajia Xiang Shiqun Shao Zhuxian Zhou Youqing Shen 

机构地区：[1]Zhejiang Key Laboratory of Smart Biomaterials and Center for Bionanoengineering,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou,Zhejiang Province,China [2]ZJU-Hangzhou Global Scientific and Technological Innovation Center,Zhejiang University,Hangzhou,Zhejiang Province,China [3]Zhejiang Key Laboratory of Smart Biomaterials and Center for Bionanoengineering,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,Zhejiang Province,China

出　　处：《Medical Review》2023年第2期184-187,共4页医学评论（英文）

基　　金：supported by the National Key Research and Development Program(2021YFA1201200);the National Natural Science Foundation of China(51833008 and 52203193);the Zhejiang Provincial Key Research and Development Program(2020C01123).

摘　　要：Cancer nanomedicines require different,even opposite,properties to voyage the cascade drug delivery process involving a series of biological barriers.Currentlyapproved nanomedicines can only alleviate adverse effects but cannot improve patient survival because they fail to meet all the requirements.Therefore,nanocarriers with synchronized functions are highly requisite to capacitate efficient drug delivery and enhanced therapeutic efficacies.This perspective article summarizes recent advances in the two main strategies for nanomedicine design,the All-in-One approach(integration of all the functions in one system)and the One-for-All approach(one functional group with proper affinity enables all the functions),and presents our views on future nanomedicine development.

关 键 词：cell membrane affinity clinical translation NANOMEDICINE One-for-All TRANSCYTOSIS 

分 类 号：TB383[一般工业技术—材料科学与工程]