氢溴酸樟柳碱注射液改善急性大面积脑梗死后脑血管储备功能的临床研究  

Clinical study on effect of Anisodine hydrobromide injection on cerebral vascular reserve function after acute massive cerebral infarction

作　　者：闫芳[1] 马乾坤[1] 刘晓洋 姜晓锋[1] 姚勇[1] YAN Fang;MA Qian-kun;LIU Xiao-yang;JIANG Xiao-feng;YAO Yong(Department of Neurology,Henan Provincial People’s Hospital,Zhengzhou 450003,China)

机构地区：[1]河南省人民医院神经内科,郑州450003

出　　处：《医药论坛杂志》2023年第8期31-34,共4页Journal of Medical Forum

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20200004)。

摘　　要：目的 研究氢溴酸樟柳碱注射液对急性大面积脑梗死后脑血管储备功能的改善作用。方法 将2021年1月—2022年9月河南省人民医院收治的60例急性大面积脑梗死患者随机划分为对照组和观察组,对照组共30例,依据《中国急性缺血性脑卒中诊治指南2018》给予常规治疗,所有患者均未使用溶栓和取栓治疗,观察组30例,在给予常规治疗的基础上,予以氢溴酸樟柳碱注射液应用,治疗剂量参考说明书,2 mg/次,1次/d, 14 d为一个疗程。所有患者治疗前后均进行血管内皮生长因子(VEGF)、血管生成素Ang-1及其受体Tie-2、成纤维细胞生长因子FGF-2的表达量检测,对比两组临床效果、美国国立卫生院神经功能缺损量表(NIHSS)评分、四组检测数据的变化及治疗安全性。结果 观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组治疗后NIHSS评分低于对照组,差异有统计学意义(P<0.05);观察组与对照组的血管内皮生长因子VEGF、血管生成素Ang-1及其受体Tie-2、成纤维细胞生长因子FGF-2的表达量检测比较,差异有统计学意义(P<0.05)。结论 氢溴酸樟柳碱注射液治疗急性大面积脑梗死具有较好的治疗效果,能够改善脑梗死后脑血管的储备功能,是有效且安全的。Objective To study the effect of Anisodine hydrobromide injection on cerebral vascular reserve function after acute massive cerebral infarction(ACI).Methods A total of 60 patients were randomly divided into control group and observation group,in the control group,30 patients were given routine treatment according to the“Chinese guideline for the diagnosis and treatment of acute ischemic stroke 2018”,thrombolysis and thrombectomy were not used in all patients,in the observation group,30 patients were treated with Anisodine hydrobromide injection on the basis of routine treatment.The treatment dosage according to the instructions was 2mg/time,once a day and 14 days.The expression of VEGF,Ang-1,Tie-2 and FGF-2 were detected before and after treatment in all patients.The clinical effect,NIHSS score,the change of four sets test data and the safety of treatment were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group(P<0.05);Compared with the control group,the NIHSS score of the observation group was significantly lower than that of the control group(P<0.05);The expressions of VEGF,Ang-1,Tie-2 and FGF-2 in the observation group and the control group were significantly different(P<0.05).Conclusion Anisodine hydrobromide injection is effective and safe in the treatment of acute massive cerebral infarction,and can improve the cerebral vascular reserve function after cerebral infarction.

关 键 词：急性大面积脑梗死 氢溴酸樟柳碱注射液 血管内皮生长因子 血管生成素Ang-1及其受体Tie-2 成纤维细胞生长因子FGF-2 NIHSS评分 

分 类 号：R743.3[医药卫生—神经病学与精神病学]