Motile cilia and microvillar:accomplices of SARS-CoV-2 in penetratingg mucuss barrier and infecting airway epithelium  

作　　者：Peng Su Fangfang Zhou Long Zhang 

机构地区：[1]Center for Infection&Immunity of International Institutes of Medicine,the fourth affliated hospital,Zhejiang University Schoolof Medicine,Yiwu322000,China [2]institutes of Biology and Medical Science,Soochow University,Suzhou 215123,China [3]Cancer Center,Zhejiang University,Hangzhou,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第4期1340-1342,共3页信号转导与靶向治疗（英文）

基　　金：the National Key R&D Program of China(2021YFA1101000,2022YFA1105200);the Chinese National Natural Science Funds(31870902,32070907,31871405,U20A20393);the National Science Fund for Distinguished Young Scholars(32125016,31925013);Zhejiang Natural Science Fund(LD19C070001);the JiangsuNational ScienceFoundation(19KJA550003);National Innovation and Entrepreneurship Training Program for College Students(202210343065).

摘　　要：Recently in Cell,Chien et al.published their new findings on severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)penetrating through the'mucosal,barrier of,respiratory by hijacking the cilia and microvilli of nasal epithelial cells,and elucidated the specific mechanism in detail using electron microscopy as well as phosphoproteomics.This study fully explained the way of SARS-CoV-2 breaking through the mucus barrier to infect nasal epithelial cells,and provided a novel direction for the blocking treatment of respiratory tract infections.The culprit of coronavirus disease 2019(COviD-19)pandemic,SARS-CoV-2.

关 键 词：RESPIRATORY EPITHELIUM 

分 类 号：R563.1[医药卫生—呼吸系统]