Autoantibodies targeting to GPER1 promote monocyte cytokines production and inflammation in systemic lupus erythematosus  

作　　者：Xinwei Zhang Hongyan Qian Yangchun Chen Yuanhui Wu Yuechi Sun Yan He Shiju Chen Guixiu Shi Yuan Liu 

机构地区：[1]Department of Rheumatology and Clinical Immunology,the First Affiliated Hospital of Xiamen University,School of Medicine,Xiamen University,Xiamen 361000,China [2]Xiamen Municipal Clinical Research Center for Immune Diseases,Xiamen 361000,China [3]Xiamen Key Laboratory of Rheumatology and Clinical Immunology,Xiamen 361000,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第4期1354-1356,共3页信号转导与靶向治疗（英文）

基　　金：the Natural Science Foundation of China(82101841,X.Z.,81601384,H.Q.,81971536,82171779,G.S.,and 81971496,Y.L.);the Natural Science Foundation of Fujian Province(2020J05301,X.Z.,2021J05292,H.Q.);the Scientific and Technological Projects of Xiamen City(3502Z20209004,G.S.and 3502Z20214ZD3001,X.Z.)。

摘　　要：Dear Editor,Systemic lupus erythematosus(SLE),one of the most common autoimmune diseases in reproductive females,is a multifactorial disease involving genetic,environmental,and hormonal factors.1 It occurs at a 9:1 female-to-male ratio,and the sex predisposition suggests that the estrogen system plays an essential role in the developing of SLE.The effects of estrogen have traditionally been attributed to the classical nuclear estrogen receptors(ERs),ERα,and ERβ,which predominantly regulate transcription.Guanine nucleotide-binding protein-coupled estrogen receptor 1(GPER1)is a transmembrane receptor for estrogen that mediates several rapid cellular effects of estrogen.2 Large amounts of autoantibodies characterize SLE,and anti-estrogen receptor autoantibodies are likely to affect the function of immune cells in SLE but are not yet fully understood.

关 键 词：ANTIBODIES LUPUS ERYTHEMATOSUS 

分 类 号：R593.24[医药卫生—内科学]