Stellettin B renders glioblastoma vulnerable to poly (ADPribose) polymerase inhibitors via suppressing homologydirected repair  

作　　者：Xin Peng Yingying Wang Shaolu Zhang Zhennan Tao Yuxiang Dai Francois X.Claret Moshe Elkabets Hou-Wen Lin Zhe-Sheng Chen Dexin Kong 

机构地区：[1]Tianjin Key Laboratory of Technologies Enabling Development of Clinical Therapeutics and Diagnostics,School of Pharmacy,Tianjin Medical University,Tianjin 300070,China [2]Key Laboratory of Immune Microenvironment and Diseases(Ministry of Education),Tianjin Medical University,Tianjin 300070,China [3]Department of Systems Biology,The University of Texas MD Anderson Cancer Center,Houston,TX 77030,USA [4]Department of Neurosurgery,the Affiliated Drum Tower Hospital,School of Medicine,Nanjing University,Nanjing 210008,China [5]The Shraga Segal Department of Microbiology,Immunology and Genetics,Faculty of Health Sciences,Ben-Gurion University of the Negev,Beer-Sheva 84105,Israel [6]Research Center for Marine Drugs,State Key Laboratory of Oncogenes and Related Genes,Department of Pharmacy,Renji Hospital,School of Medicine,Shanghai Jiaotong University,Shanghai 200127,China [7]Department of Pharmaceutical Sciences,College of Pharmacy and Health Sciences,St.John’s University,Queens,NY 11439,USA

出　　处：《Signal Transduction and Targeted Therapy》2023年第4期1388-1391,共4页信号转导与靶向治疗（英文）

基　　金：the National Natural Science Foundation of China(82073890,81673464,and 82061148017,to DK,22137006 and 82104054,to HW L);Fellowship of China Postdoctoral Science Foundation(2021M702464 to XP);Postgraduate Innovation Fund of 13th Five-Year comprehensive investment of Tianjin Medical University(YJSCX201806 to XP).SF295 cell line was kindly provided by the National Cancer Institute,National Institutes of Health,USA.We thank Dr.Xi Chen from Tianjin Key Laboratory of Ophthalmology and Visual Science,Tianjin Eye Institute,Tianjin Eye Hospital for assistance in spectrometry proteomics data analysis.

摘　　要：Dear Editor,Glioblastoma(GBM)is one of the most fatal brain tumors.Current first-line post-surgery regimens for GBM including radiotherapy and temozolomide(TMZ)chemotherapy show very limited efficacy.1,2 Novel therapeutic approaches for GBM patients are urgently needed.Natural products are important sources for drug discovery,especially in the field of cancer treatment.3 We previously isolated stellettin B(STELB)(Fig.1a)from marine sponge(Jaspis stellifera)and reported the remarkable and specific anticancer activities.Recently,a series of stellettins has been totally synthesized and the core chemical structure has been indicated.4 However,the specific mechanism and its role in regulating tumor biology remain largely unknown.

关 键 词：CHEMOTHERAPY SURGERY RENDER 

分 类 号：R739.4[医药卫生—肿瘤]