Small molecule metabolites:discovery of biomarkers and therapeutic targets  

作　　者：Shi Qiu Ying Cai Hong Yao Chunsheng Lin Yiqiang Xie Songqi Tang Aihua Zhang 

机构地区：[1]International Advanced Functional Omics Platform,Scientific Experiment Center,Hainan General Hospital(Hainan Affiliated Hospital of Hainan Medical University),College of Chinese Medicine,Hainan Medical University,Xueyuan Road 3,Haikou 571199,China [2]Graduate School,Heilongjiang University of Chinese Medicine,Harbin 150040,China [3]First Affiliated Hospital,Harbin Medical University,Harbin 150081,China [4]Second Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150001,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第4期1684-1720,共37页信号转导与靶向治疗（英文）

基　　金：the generous support from the Program of Natural Science Foundation of State(Grant No.81973745,82104733,81302905);Talent Lift Engineering Project of China Association of TCM(QNRC2-B06);Natural Science Foundation of Heilongjiang Province(YQ2019H030)。

摘　　要：Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is wellrecognizedhallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension,are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers couldlead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity andselectivity are desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool for metabolicbiomarker and pathway analysis, for revealing possible mechanisms of human various diseases and deciphering therapeuticpotentials. It could help identify functional biomarkers related to phenotypic variation and delineate biochemical pathwayschanges as early indicators of pathological dysfunction and damage prior to disease development. Recently, scientists haveestablished a large number of metabolic profiles to reveal the underlying mechanisms and metabolic networks for therapeutictarget exploration in biomedicine. This review summarized the metabolic analysis on the potential value of small-moleculecandidate metabolites as biomarkers with clinical events, which may lead to better diagnosis, prognosis, drug screening andtreatment. We also discuss challenges that need to be addressed to fuel the next wave of breakthroughs.

关 键 词：DIAGNOSIS THERAPEUTIC SMALL 

分 类 号：R589[医药卫生—内分泌]