益智仁中2个新的萜苷化合物  

Two new terpene glycosides from the Alpiniae Oxyphyllae Fructus

作　　者：朱跃通 陈豪 刘晓宁 李恺之 刘双晶 冯卫生[1,2] 程永现 王彦志 ZHU Yue-tong;CHEN Hao;LIU Xiao-ning;LI Kai-zhi;LIU Shuang-jing;FENG Wei-sheng;CHENG Yong-xian;WANG Yan-zhi(School of Pharmacy,Henan University of Chinese Medicine,Zhengzhou 450046,China;Co-construction of Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of P.R.China,Zhengzhou 450046,China;School of Pharmaceutical Sciences,Institute for Inheritance-Based Innovation of Chinese Medicine,Shenzhen University,Shenzhen 518060,China)

机构地区：[1]河南中医药大学药学院,河南郑州450046 [2]呼吸疾病中医药防治省部共建协同创新中心,河南郑州450046 [3]深圳大学药学院,中医药守正创新研究院,广东深圳518060

出　　处：《药学学报》2023年第5期1283-1287,共5页Acta Pharmaceutica Sinica

摘　　要：运用MCI Gel、Sephadex LH-20、ODS和硅胶等柱色谱,结合半制备液相、TLC等分离方法,从益智仁正丁醇部位中分离纯化得到4个萜苷类化合物。运用现代波谱学方法(1D、2D NMR、UV、IR、MS等)对所分离得到的化合物进行结构鉴定,并运用计算ECD和酸水解的方法确定了新化合物的绝对构型,其中化合物1和2为新化合物,化合物3和4为首次从益智仁中分离得到。Two undescribed terpene glycosides and two compounds were isolated from the n-butanol fraction of Alpiniae Oxyphyllae Fructus by using various chromatographic methods,including MCI Gel,Sephadex LH-20,ODS,silica gel and semi-preparative HPLC.The structures of the isolated compounds were identified by spectroscopy methods(1D,2D NMR,UV,IR,MS,etc.),and the absolute configuration of the compound 1 was determined by ECD calculation and acid hydrolysis.Compounds 1 and 2 are new compound,and compounds 3 and 4 were isolated from Alpiniae Oxyphyllae Fructus for the first time.

关 键 词：益智仁 化学成分 萜苷 半日花烷型二萜 香芹酚 酸水解 

分 类 号：R284[医药卫生—中药学]