创面喷洒铝镁加混悬液联合艾普拉唑对上消化道息肉患者ESD术后溃疡创面愈合效果的影响  

Effect of Trauma Spraying Almagate Suspension Combined with Eprazole on Ulcer Wound Healing after ESD in Patients with Upper Gastrointestinal Polyps

作　　者：黄志豪[1] 林梓瀚 李静慧 HUANG Zhihao;LIN Zihan;LI Jinghui(Department of Gastroenterology,Puning Overseas Chinese Hospital,Jieyang,Guangdong Province,515300 China)

机构地区：[1]普宁华侨医院消化内科,广东揭阳515300

出　　处：《中外医疗》2023年第9期132-136,共5页China & Foreign Medical Treatment

摘　　要：目的探究创面喷洒铝镁加混悬液联合艾普拉唑针对上消化道息肉患者内镜下黏膜剥离术(endoscopic submucosal dissection,ESD)后溃疡创面愈合效果的影响。方法随机选取2020年1月—2022年3月于普宁华侨医院行ESD术的上消化道息肉患者70例,按照随机数表法分为观察组与对照组,各35例,其中观察组采用铝镁加混悬液联合艾普拉唑,对照组采用艾普拉唑,比较术后2周、4周时两组患者术后溃疡面积、愈合情况及幽门螺杆菌(Hp)根除率、出血差异。结果术后2周、4周时两组溃疡面积均小于初始溃疡面积,术后4周时均小于术后2周时,且观察组术后4周时小于对照组[(429.40±239.26)mm^(2)vs(546.23±234.15)mm^(2)],差异有统计学意义(t=2.064,P<0.05);两组间术后2周时溃疡面积比较,差异无统计学意义(t=1.060,P>0.05)。术后2周时,两组间Hp根除率比较,差异无统计学意义(χ^(2)=0.612,P>0.05);术后4周时,两组Hp根除率均优于同组术后2周时,且观察组优于对照组(77.14%vs 51.43%),差异有统计学意义(χ^(2)=5.040,P<0.05)。术后2周时,两组间愈合率比较,差异无统计学意义(χ^(2)=2.696,P>0.05);术后4周时观察组愈合率高于对照组(51.43%vs 25.71%),差异有统计学意义(χ^(2)=4.883,P<0.05)。术后2周、4周时两组间出血率比较,差异无统计学意义(χ^(2)=1.196、0.861,P>0.05)。结论铝镁加混悬液联合艾普拉唑可有效防止Hp感染,加快溃疡创面愈合。Objective To investigate the effect of trauma spraying Almagate suspension combined with eprazole on ulcer wound healing after endoscopic submucosal dissection(ESD)in patients with upper gastrointestinal polyps.Methods Seventy patients with upper gastrointestinal polyps undergoing ESD in Puning Overseas Chinese Hospital from January 2020 to March 2022 were randomly selected and divided into the observation group and control group according to the random number table method,with 35 cases each.Among them,the observation group used Almagate suspension combined with eprazole and the control group used eprazole.The postoperative ulcer area and healing as well as the helicobacter pylori(Hp)eradication rate and bleeding differences between the two groups at 2 and 4 weeks postoperatively were compared.Results The ulcer area in both groups was smaller than the initial ulcer area at 2 and 4 weeks postoperatively,and the ulcer area at 4 weeks postoperatively was smaller than that at 2 weeks postoperatively,and the ulcer area in the observation group was smaller than that in the control group at 4 weeks postoperatively[(429.40±239.26)mm^(2)vs(546.23±234.15)mm^(2)],and the difference was statistically significant(t=2.064,P<0.05).There was no statistically significant difference between the two groups in terms of ulcer area at 2 weeks postoperatively(t=1.060,P>0.05).There was no statistically significant difference in the Hp eradication rate between the two groups at 2 weeks postoperatively(t=0.612,P>0.05).At 4 weeks postoperatively,the Hp eradication rate in both groups was greater than that in the same group at 2 weeks postoperatively,and the observation group was greater than that in the control group(77.14%vs 51.43%),and the difference was statistically significant(χ^(2)=5.040,P<0.05).At 2 weeks postoperatively,there was no statistically significant difference in the healing rate between the two groups(χ^(2)=2.696,P>0.05).The healing rate in the observation group was greater than that in the control group at 4 weeks po

关 键 词：铝镁加混悬液 艾普拉唑 上消化道息肉 ESD术后 溃疡创面 

分 类 号：R735[医药卫生—肿瘤]