Integrated and dual-responsive lipopeptide nanovector with parallel effect to tumor and micro-environment regulation by efficient gene and drug co-delivery  

作　　者：Xiaobing Chen Huan Yang Xu Song Hong Liang Yu Wei Jiao Lu Matthias Barz Rongrong Jin Yu Nie 

机构地区：[1]National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610064,China [2]Leiden Academic Center for Drug Research(LACDR),Leiden University,Leiden 2333 CC,The Netherlands [3]Department of Pharmacy,Sichuan Academy of Medical Sciences&Sichuan Provincial People's Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu 610072,China

出　　处：《Chinese Chemical Letters》2023年第5期420-426,共7页中国化学快报（英文版）

基　　金：financially supported by National Natural Science Foundation of China(NSFC,Nos.81873921 and 51903174);Sino-German Cooperation Group Project(No.GZ1512);China Postdoctoral Science Foundation(No.2021M702772);Chengdu Science and Technology Program(No.2020-GH02-00007-HZ);Sichuan University Postdoctoral Interdisciplinary Innovation Startup Foundation and the Fundamental Research Funds for Central Universities(No.2021SCU12070)。

摘　　要：The integrated lipopeptide(RVA)/gene complexes are fabricated with bi-directional regulation on tumor cells and micro-environment.After self-assembling and target coating modification,the poly(γ-glutamic acid)(γ-PGA)/RVA nano-vectors can sequentially respond to pH&redox stimuli,and guarantee efficient therapeutic gene delivery and control release of all-trans retinoic acid.The design provides a facile but promising strategy to treat refractory cancers.

关 键 词：Gene delivery Integrated co-delivery Dual-responsive LIPOPEPTIDE Tumor micro-environment regulation 

分 类 号：R730[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]