Surfactant-regulated acetylpyrene assemblies as fluorescent probes for identifying heme proteins in an aqueous solution  

作　　者：Binbin Yuan Shuangshuang Long Huamin Wang Qing Luo Ke Zeng Shuqin Gao Yingwu Lin 

机构地区：[1]School of Chemistry and Chemical Engineering,University of South China,Hengyang 421001,China

出　　处：《Chinese Chemical Letters》2023年第5期466-469,共4页中国化学快报（英文版）

基　　金：financially supported by the Scientific Research Fund of Hunan Education Department,China(Nos.21B0421,20C1636);The National Natural Science Foundation of China(No.21977042)。

摘　　要：Heme proteins play various important roles in a variety of physiological and pathological processes.Surfactant assemblies have drawn great attention in fabricating fluorescent sensors to detect and identify proteins.In this study,an acetylpyrene fluorophore containing imidazole HP-1 was synthesized,and it could be well modulated by an anionic surfactant sodium dodecyl sulfate(SDS).The selected ensemble based on HP-1/SDS assemblies exhibited selective fluorescence sensing performance towards the heme proteins,including neuroglobin(Ngb),myoglobin(Mb)and cytochrome c(Cyt c).Besides,phospholipid DMPC vesicles as membrane models were particularly explored the association process between the heme protein Mb and membrane.The present work showed that Mb induced the lysis of DMPC liposomes visualized by transmission electron microscopy and optical microscope.

关 键 词：Heme proteins SURFACTANT Fluorescent sensor Acetylpyrene LIPOSOME 

分 类 号：O657.3[理学—分析化学]