Sequentially responsive size reduction and drug release of core-satellite nanoparticles to enhance tumor penetration and effective tumor suppression  

作　　者：Jiayi Sun Jingyang Li Xi Li Lu Yang Yitong Liu Huile Gao Li Xiang 

机构地区：[1]State Key Laboratory of Southwestern Chinese Medicine Resources,Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China [2]Public Health Clinical Center of Chengdu,Chengdu 610061,China [3]The Third Affiliated Hospital of Chengdu University of TCM/Chengdu Pidu District Hospital of Traditional Chinese Medicine,Chengdu 611730,China [4]West China School of Pharmacy,Sichuan University,Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2023年第5期489-493,共5页中国化学快报（英文版）

基　　金：supported by Xinglin Scholar Research Premotion Project of Chengdu University of TCM(No.MPRC2021031)。

摘　　要：Poor tumor accumulation remains a serious challenge for nanomedicines to achieve ideal antitumor outcomes.The different size preferences for systematic circulation,tumor retention and deep permeation have attracted great attention when designing antineoplastic nano-delivery system.Herein,we developed a nano-system which can shrink its size in tumor microenvironment to achieve better tumor retention and penetration.In this work,the cationic bovine serum albumin-protected,doxorubicin-loaded gold nanoclusters(CAuNC-DOX)and amino-functionalized mesoporous silica nanoparticles(MSN)are connected by Fe^(2+)and are further coated with hyaluronic acid(HA)to obtain a core-satellite MSN-Fe-CAuNCDOX@HA nano system(MFADH).When reaching the tumor site,the HA shell,which endows the system with both good biocompatibility and preferable tumor targeting ability,was disintegrated,followed by acid-stimulated release of small-sized pharmacological unit—CAuNC-DOX for further tumor penetration.As demonstrated in both in vitro and in vivo results,MFADH showed excellent antitumor effect,providing a proof of concept for the feasibility of shrinkable nanoplatforms in tumor treatment.

关 键 词：Size reducible Tumor penetration Core-satellite structure Mesoporous silica nanoparticles Gold nanoclusters Experimental techniques 

分 类 号：R730[医药卫生—肿瘤] TQ460.1[医药卫生—临床医学] TB383.1[化学工程—制药化工]