神经内镜经鼻蝶入路切除无功能性垂体腺瘤的效果及对视觉功能的影响研究  

Effectiveness of Neuroendoscopic Transsphenoidal Approach for Resection of Non-functional Pituitary Adenoma and the Effect on Visual Function

作　　者：杨震宇 YANG Zhen-yu(Department of Endocrinology,Second Department of Jiamusi Cen-tral Hospital,Jiamusi,Heilongjiang,154002,China)

机构地区：[1]佳木斯市中心医院二部内分泌科,黑龙江佳木斯154002

出　　处：《黑龙江医学》2023年第11期1309-1311,共3页Heilongjiang Medical Journal

摘　　要：目的:观察神经内镜经鼻蝶入路切除无功能性垂体腺瘤(NFPA)的效果及对视觉功能的影响。方法:选取2019年6月—2021年6月佳木斯市中心医院内分泌科收治的86例NFPA患者作为研究对象,采用随机数表法分为对照组和观察组,每组各43例。对照组给予显微镜经鼻蝶入路切除术,观察组给予神经内镜经鼻蝶入路切除术。比较两组患者肿瘤切除率、围术期指标、患侧眼球加权视野指数(VFI)、视野平均缺损(MD)、模式标准差(PSD)及并发症发生情况。结果:观察组肿瘤全切除率高于对照组,差异有统计学意义(χ2=4.690,P<0.05)。观察组手术时间长于对照组,观察组术中失血量少于对照组,观察组住院时间短于对照组,差异有统计学意义(t=8.188、18.086、23.352,P<0.05)。术后,两组患者患侧眼球VFI增加,MD、PSD减少,且观察组患侧眼球VFI高于对照组,MD、PSD低于对照组,差异有统计学意义(t=4.715、39.665、24.263,P<0.05)。观察组并发症发生率明显低于对照组,差异有统计学意义(χ2=4.690,P<0.05)。结论:神经内镜经鼻蝶入路切除NFPA可明显提高患者肿瘤全切除率,促进其视觉功能恢复,降低其术后并发症发生率。Objective:To observe the effect of neuroendoscopic transsphenoidal approach to remove non-functional pituitary adenoma(NFPA)and the effect on visual function.Methods:86 patients with NFPA admitted to the hospital from June 2019 to June 2021 were selected as the study population and were divided into control group and observation group using the random num⁃ber table method,with 43 cases in each group.The control group was given microscopic transsphenoidal approach for resection,and the observation group was given neuroendoscopic transsphenoidal approach for resection.The tumor resection rate,periopera⁃tive indicators,weighted visual field index(VFI)of the affected eye,mean visual field defect(MD),pattern standard deviation(PSD),and complications occurred in the two groups were compared.Results:The total tumor resection rate in the observation group was higher than that in the control group,and the difference was statistically significant(χ2=4.690,P<0.05).The operating time of the observation group was longer than that of the control group,the intraoperative blood loss of the observation group was less than that of the control group,and the hospital stay of the observation group was shorter than that of the control group,with sta⁃tistically significant differences(t=8.188,18.086,23.352,P<0.05).After surgery,the VFI of the affected eye increased and the MD and PSD decreased in both groups,and the VFI of the affected eye in the observation group was higher than that in the control group,and the MD and PSD were lower than those in the control group,with statistically significant differences(t=4.715,39.665,24.263,P<0.05).The incidence of complications in the observation group was significantly lower than that in the control group,and the difference was statistically significant(χ2=4.690,P<0.05).Conclusion:Neuroendoscopic transsphenoidal approach for NFPA resection can significantly improve the total tumor resection rate,promote the recovery of their visual function,and re⁃duce the incidence of their postopera

关 键 词：神经内镜 经鼻蝶入路 无功能性垂体腺瘤 视觉功能 视野平均缺损 

分 类 号：R781.63[医药卫生—口腔医学]