经直肠剪切波弹性成像技术联合血清CEA、PSA、FPSA对前列腺良恶性病变的鉴别诊断价值研究  

Differential Diagnosis Value Study of Transrectal Shear Wave Elastography Combined with Serum CEA,PSA and FPSA in the Benign and Malignant Prostate Diseases

作　　者：李苗苗 杨晓[1] 魏杰[1] 袁长翮 张贵平 徐杰 武悦 LI Miao-miao;YANG Xiao;WEI Jie;YUAN Chang-he;ZHANG Gui-ping;XU Jie;WU Yue(Department of Ultrasonography,Hefei Second People's Hospital,Hefei,Anhui,230012,China)

机构地区：[1]合肥市第二人民医院超声科,安徽合肥230012

出　　处：《现代生物医学进展》2023年第10期1997-2000,1992,共5页Progress in Modern Biomedicine

基　　金：安徽省科技攻关项目(1501Id04056)。

摘　　要：目的:研究经直肠剪切波弹性成像技术(TRSWE)联合血清癌胚抗原(CEA)、前列腺特异性抗原(PSA)、游离前列腺特异性抗原(FPSA)对前列腺良恶性病变的鉴别诊断价值。方法:选取合肥市第二人民医院2019年1月~2022年6月收治的90例前列腺病变患者,根据病理检查分为前列腺癌组(47例)和前列腺良性病变组(43例)。对所有前列腺病变患者均行TRSWE检查,分析前列腺良恶性病变的图像差异以及弹性模量最大值(Emax)、弹性模量平均值(Emean)。检测所有前列腺病变患者的血清CEA、PSA、FPSA水平并进行对比。采用受试者工作特征(ROC)曲线分析明确Emax值、Emean值以及血清CEA、PSA、FPSA水平联合诊断前列腺良恶性病变的效能。结果:前列腺癌组Emax值、Emean值均高于前列腺良性病变组(均P<0.05)。前列腺癌组血清CEA、PSA及FPSA水平均高于前列腺良性病变组(均P<0.05)。经ROC曲线分析发现,Emax值、Emean值以及血清CEA、PSA、FPSA水平联合检测诊断前列腺良恶性病变的效能优于上述5项指标单独检测。结论:TRSWE联合血清CEA、PSA、FPSA对前列腺良恶性病变的鉴别诊断价值较高,可有效提升前列腺癌的检出率,可能值得临床推广应用。Objective:To study the differential diagnosis value of transrectal shear wave elastography(TRSWE)combined with serum carcinoembryonic antigen(CEA),prostate specific antigen(PSA)and free prostate specific antigen(FPSA)in the the benign and malignant prostate diseases.Methods:90 patients with prostate disease who were admitted to Hefei Second People's Hospital from January 2019 to June 2022 were selected,and they were divided into prostate cancer group(47 cases)and benign prostate disease group(43 cases)according to pathological examination.TRSWE examination was performed on all patients with prostate diseases,the image differences,maximum elastic modulus(Emax)and mean elastic modulus(Emean)of benign and malignant prostate diseases were analyzed.Serum CEA,PSA and FPSA levels of all patients were detected and compared.Receiver operating characteristic(ROC)curve was used to analyze the combined efficacy of Emax value,Emean value and serum CEA,PSA and FPSA levels in the diagnosis of benign and malignant prostate diseases.Results:The Emax value and Emean value in the prostate cancer group were higher than those in the benign prostate disease group(all P<0.05).Serum CEA,PSA and FPSA levels in the prostate cancer group were higher than those in the benign prostate disease group(all P<0.05).The ROC curve analysis showed that the combined detection of Emax value,Emean value and serum CEA,PSA,FPSA levels in the diagnosis of benign and malignant prostate diseases was superior to the single detection of the above five indicators.Conclusion:TRSWE combined with serum CEA,PSA and FPSA has a high value in differential diagnosis of benign and malignant prostate diseases,which can effectively improve the detection rate of prostate cancer,and which may be worthy of clinical application.

关 键 词：前列腺癌 前列腺增生 经直肠剪切波弹性成像技术 CEA PSA FPSA 诊断价值 

分 类 号：R737.25[医药卫生—肿瘤]