中心粒周蛋白在牙颌面及相关发育畸形中的作用及机制研究进展  

Advance in the role and mechanism of pericentrin in development dento-maxillofacial deformities and other malformations

作　　者：张筠 代庆刚[1] 吴轶群[1] ZHANG Yun;DAI Qing-gang;WU Yi-qun(Second Dental Center,Shanghai Ninth People's Hospital,Shanghai Jioo Tong University Se hool of Medicine,College of Stomatology,Shanphai Jioo Tong Uniersiy:National Center for Stomatology,National Clinical Research Center for Oraul Disease,Shanghai Key Laboratory of Stomatology:Shanghai Research Insinte of Stomotology.Shanghai 201999,China)

机构地区：[1]上海交通大学医学院附属第九人民医院口腔第二门诊部,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海200011

出　　处：《中国口腔颌面外科杂志》2023年第3期279-285,共7页China Journal of Oral and Maxillofacial Surgery

基　　金：国家自然科学基金(82271004);上海市自然科学基金(21ZR1437700,21ZR1436900);上海交通大学医学院附属第九人民医院生物样本库专项基金(YBKB202101);上海交通大学医学院附属第九人民医院、上海交通大学口腔医学院研究型学科基金项目(KQYJXK2020)。

摘　　要：中心粒周蛋白(pericentrin,PCNT)是一种中心体周围蛋白,在有丝分裂、减数分裂等多个生物学行为中发挥着重要作用。PCNT突变可导致多种牙颌面部畸形,包括严重颅颌面骨发育畸形和牙发育异常。虽然临床症状多有报道,但是PCNT在口腔领域的相关研究还十分有限。为了更好理解PCNT相关颅颌面畸形的临床表现及发病机制,本文综述了近年来发表的PCNT的功能和致病机制相关的研究进展,为以后开展PCNT在牙-牙周组织及颅颌面骨发育中的功能研究提供参考。Pericentrin(PCNT)is a centrosomal protein that plays an important role in many biological behaviors such as mitosis and meiosis.Mutations in PCNT can cause a variety of dento-maxillofacial deformities,including severe craniofacial dysplasia and malformation of dental development.Although many clinical symptoms that related with PCNT have been reported,the research in the stomatological medical field is still very limited.In order to better understand the clinical manifestations and pathogenesis of PCNT-related craniomaxillofacial deformities,this article reviewed the research progress on the pathogenic mechanism of PCNT published in recent years,and may hopefully provide theoretical basis for future study on the function of PCNT in craniofacial growth and dento-peridontal development.

关 键 词：中心粒周蛋白 牙颌面发育畸形 牙发育畸形 小头畸形-骨发育不良-原始性侏儒综合征 

分 类 号：R782.2[医药卫生—口腔医学]