鼻咽癌放化疗后继发舌鳞癌、口咽癌及牙龈癌1例并文献复习  

Tongue squamous cell carcinoma,oropharyngeal carcinoma and gingival carcinoma secondary to nasopharyngeal carcinoma:a case report and literature review

作　　者：王博 沈月洪 杨宏宇 WANG Bo;SHEN Yue-hong;YANG Hong-yu(Zunyi Medical University,Zunyi 563000 Guichou Porince;Deparment of Oral and Mrillfociol Surgery,Peking Unirersiry,Shenzhen Hospial.Shenzhen 518036,Guangdong Povince,China)

机构地区：[1]遵义医科大学,贵州遵义563000 [2]北京大学深圳医院口腔颌面外科,广东深圳518036

出　　处：《中国口腔颌面外科杂志》2023年第3期301-305,共5页China Journal of Oral and Maxillofacial Surgery

基　　金：广东省自然科学基金(2019A1515011911);深圳市科技创新委员会基础研究重点项目(JCYJ20200109140208058)。

摘　　要：鼻咽癌(nasopharyngeal carcinoma,NPC)在是一种相对罕见的疾病,具有独特的地理分布,但其在东南亚地区是高发恶性肿瘤。鼻咽癌大部分为低分化鳞癌(98%),首选放射治疗,而放化疗被认为具有双重性,既能治癌,又能致癌。头颈部癌症在放疗后发生放射性颌骨坏死的概率在1%~3%,且主要发生于下颌骨。本文报告1例鼻咽癌放化疗后相继发生左侧舌鳞状细胞癌、口咽癌以及下颌牙龈癌,并在牙龈癌术后发生放射性颌骨骨髓炎的病例,结合文献复习,对其病史、临床表现、治疗和预后进行讨论。Nasopharyngeal carcinoma(NPC)is a relatively rare disease in the world,with a unique geographical distribution,but high incidence in Southeast Asia.Nasopharyngeal carcinoma is mostly poorly differentiated squamous cell carcinoma(98%)and radiotherapy is the first choice of treatment.Radiotherapy and chemotherapy have been considered to have a duality,which can treat cancer and cause cancer.The probability of radionecrosis of the jaw after radiotherapy for head and neck cancer is 1%-3%,mainly occurring in the mandible.This paper reported a case of left tongue squamous cell carcinoma,left oropharyngeal carcinoma and left lower gingival carcinoma after radiotherapy and chemotherapy for nasopharyngeal carcinoma,and the occurrence of radiation osteomyelitis of the jaw.The history,clinical manifestations,treatment and prognosis of this case were discussed based on reviewing the literature.

关 键 词：鼻咽癌 放射治疗 舌鳞状细胞癌 口咽癌 牙龈癌 放射性颌骨骨髓炎 

分 类 号：R739.8[医药卫生—肿瘤]