应用微生物制剂缓解高草酸尿症的研究进展  

Research progress on the application of microbial agents to alleviate hyperoxaluria

作　　者：许明月 谭卓铭 王光强[1] 熊智强[1] 宋馨[1] 杨昳津 张汇[1] 艾连中[1] 夏永军[1] XU Mingyue;TAN Zhuoming;WANG Guangqiang;XIONG Zhiqiang;SONG Xin;YANG Yijin;ZHANG Hui;AI Lianzhong;XIA Yongjun(Shanghai Engineering Research Center of Food Microbiology,School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200000,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海食品微生物工程研究中心,上海200000

出　　处：《食品与发酵工业》2023年第11期288-297,共10页Food and Fermentation Industries

基　　金：国家杰出青年科学基金项目(32025029);2021年度“中国食品科学技术学会食品科技基金-伊利健康科学基金”项目(2021-Y06);上海市教育委员会科研创新计划项目(2101070007800120);上海食品微生物工程技术研究中心项目(19DZ2281100)。

摘　　要：草酸在人体内过度积累会导致高草酸尿症且易引发肾结石,目前尚无特效药物能够缓解高草酸尿症。肠道中存在草酸降解功能的微生物,可以通过多种途径降解人体内的草酸。肠-肾轴途径表明,正常个体的肠道微生物多样性和草酸降解菌的丰度显著高于高草酸尿症患者,所以增加患者肠道中的草酸降解微生物是缓解该症的潜在方法。具有降解草酸功能的产草酸甲酸杆菌、乳杆菌、链球菌和双歧杆菌等菌株已广泛用于人体内。文章总结了治疗高草酸尿症的微生物制剂及其缓解机制,包括粪便中的功能菌群、益生菌、基因工程菌等,以期为利用微生物制剂缓解高草酸尿症的相关研究提供理论参考。Excessive accumulation of oxalate in the human body will lead to hyperoxaluria,which is easy to cause kidney stones.At present,there are no specific drugs can alleviate hyperoxaluria,but there are oxalate-degrading microorganisms in the intestine that can degrade oxalate in the body through various pathways.The gut-kidney axis pathway indicated that the gut microbial diversity and the abundance of oxalate-degrading bacteria are significantly higher in normal human than those in patients with hyperoxaluria,so increasing the oxalate-degrading microorganisms in the gut of patients is a potential way to alleviate the disease.Strains of Oxalobacter formigenes,Lactobacillus,Streptococcus and Bifidobacterium with oxalate degrading function have been widely used in vivo.This article summarizes the microbial agent and mechanisms of alleviation for the treatment of hyperoxaluria,including functional flora in feces,probiotics,genetically engineered bacteria,in order to provide theoretical reference for the research on the treatment of hyperoxaluria with probiotics.

关 键 词：益生菌 肠道菌群 高草酸尿症 肾结石 草酸降解率 

分 类 号：R589[医药卫生—内分泌]