幽门螺杆菌感染合并脑梗死患者认知障碍研究进展  

Research progress of cognitive impairment in patients with Helicobacter pylori infection combined with cerebral infarction

作　　者：郭昕瑜 高欢欢 郭瑞芳[1] GUO Xin-yu;GAO Huan-huan;GUO Rui-fang

机构地区：[1]承德医学院附属医院,067000

出　　处：《中国疗养医学》2023年第7期705-709,共5页Chinese Journal of Convalescent Medicine

摘　　要：脑梗死(cerebral infarction,CI)是目前我国临床发病率较多且危害较大的疾病,认知功能障碍是其常见并发症,脑梗死后认知功能障碍(PSCI)对患者的生命及生活质量造成了严重影响。幽门螺杆菌(helicobacter pylori,Hp)作为我国感染率较高的一种病原体,参与了多种系统疾病的发生与发展,其可能通过激活体内多种炎性因子、过氧化作用、胰岛素抵抗等多种机制,从而增加脑梗死的发生风险,本文介绍了Hp通过消化系统疾病、动脉粥样硬化、血清淀粉样蛋白酶A、8羟基脱氧鸟苷与PSCI的相关性,以探讨脑梗死合并Hp感染患者认知功能障碍加重的可能机制,为临床预防及治疗提供更可靠的依据。Cerebral infarction(CI)is a prevalent disease with a high incidence and great health harm.Cognitive dysfunction is a common complication of CI,and post-stroke cognitive impairment(PSCI)poses a severe influence on the live and quality of life.Helicobacter pylori(Hp)is a pathogen with a high infection rate in China,which is involved in the occurrence and development of various systemic diseases.Hp infection increases the risk of CI by activating inflammatory factors,oxidation and insulin resistance.This review describes the correlation between Hp infection and PSCI via the digestive system diseases,atherosclerosis,serum amyloid proteinase A,and 8-hydroxydeoxyguanosine,thus exploring the mechanism underlying PSCI in CI patients combined with Hp infection and providing references for clinical prevention and treatment.

关 键 词：认知功能障碍 幽门螺杆菌 脑梗死 

分 类 号：R573.1[医药卫生—消化系统] R743.3[医药卫生—内科学]