奥美拉唑注射液治疗消化性溃疡上消化道出血的临床效果  

Clinical effect of omeprazole injections on upper gastrointestinal bleeding induced by peptic ulcers

作　　者：王紫琼 杨玉霞 程建国 WANG Zi-qiong;YANG Yu-xia;CHENG Jian-guo

机构地区：[1]中部战区总医院第四派驻门诊部,湖北武汉430035

出　　处：《中国疗养医学》2023年第7期773-776,共4页Chinese Journal of Convalescent Medicine

摘　　要：目的探讨消化性溃疡上消化道出血奥美拉唑注射液治疗的临床效果。方法回顾性选取2019年8月至2021年2月中部战区总医院消化内科消化性溃疡上消化道出血患者100例,依据用药方法分为奥美拉唑注射液组、西咪替丁针治疗组两组,每组各50例,统计分析两组患者的空腹胃液pH值、血清学指标、止血情况、临床疗效、出血量、止血时间、潜血转阴时间、住院时间、不良反应发生情况。结果用药后1 d、2 d、3 d,奥美拉唑注射液组患者的空腹胃液pH值均高于西咪替丁针治疗组(t=5.784,8.286,5.746,P<0.05)。用药后,奥美拉唑注射液组患者的血清胃泌素-17(G-17)水平高于西咪替丁针治疗组(P<0.05),血清胃蛋白酶原Ⅰ(PGⅠ)、PGⅡ水平均低于西咪替丁针治疗组(P<0.05)。用药后1 d,奥美拉唑注射液组患者的止血率高于西咪替丁针治疗组(χ^(2)=4.596,P<0.05)。奥美拉唑注射液组患者治疗的总有效率94.00%(47/50)高于西咪替丁针治疗组80.00%(40/50)(Z=2.100,P<0.05)。奥美拉唑注射液组患者的出血量少于西咪替丁针治疗组(t=17.453,P<0.05),止血时间短于西咪替丁针治疗组(t=8.676,P<0.05),潜血转阴时间短于西咪替丁针治疗组(t=12.414,P<0.05),住院时间短于西咪替丁针治疗组(t=7.579,P<0.05)。奥美拉唑注射液组和西咪替丁针治疗组患者的不良反应发生率之间的差异无统计学意义(χ^(2)=0,P>0.05)。结论消化性溃疡上消化道出血奥美拉唑注射液治疗的临床效果较西咪替丁针治疗好。Objective To investigate the clinical effect of omeprazole injections on the treatment of upper gastrointestinal bleeding induced by peptic ulcers.Methods A total of 100 cases of patients with upper gastrointestinal bleeding induced by peptic ulcers who were treated in the Department of Gastroenterology,General Hospital of Central Theater Command from August 2019 to February 2021 were retrospectively selected.According to the medication methods,they were divided into omeprazole injection group and cimetidine injection group,with 50 cases in each group.The pH values of fasting gastric juice,serological indexes,hemostasis,clinical efficacy,amount of bleeding,hemostasis time,time of negative conversion of occult blood,hospital stay and incidence of adverse reactions of the two groups were compared.Results The pH value of fasting gastric juice in the omeprazole injection group was significantly higher than that in the cimetidine injection group on day 1,2 and 3(t=5.784,8.286,5.746,respectively;all P<0.05).After treatment,serum level of gastrin-17(G-17)in the omeprazole injection group was significantly higher than that in the cimetidine injection group(P<0.05),and serum levels of pepsinogenⅠ(PGⅠ)and PGⅡwere significantly lower(P<0.05).On day 1,the hemostatic rate in the omeprazole injection group was significantly higher than that in the cimetidine injection group(χ^(2)=4.596,P<0.05).The total effective rate in the omeprazole injection group was significantly higher than that in the cimetidine injection group(94.00%[47/50]VS 80.00%[40/50],Z=2.100,P<0.05).The amount of bleeding in the omeprazole injection group was significantly less than that in the cimetidine injection group(t=17.453,P<0.05),and the hemostasis time,time of negative conversion of occult blood and hospital stay were significantly shorter than those in the cimetidine injection group(t=8.676,P<0.05;t=12.414,P<0.05;t=7.579,P<0.05).There was no significant difference in the incidence of adverse reactions between groups(χ^(2)=0,P>0.05).Conclusion T

关 键 词：消化性溃疡 上消化道出血 西咪替丁针 奥美拉唑注射液 PH值 

分 类 号：R573.2[医药卫生—消化系统]