盐酸洛哌丁胺联合痛泻宁颗粒对腹泻型肠易激综合征的临床疗效  

Clinical efficacy of loperamide hydrochloride combined with Tongxiening Granules in treatment of patients with diarrhea-predominant irritable bowel syndrome

作　　者：黄洋[1] HUANG Yang(the Third Department of Hemorrhoids and Fistula,the Third Hospital Affiliated to Liaoning University of Traditional Chinese Medicine,Shenyang,Liaoning,110003)

机构地区：[1]辽宁中医药大学附属第三医院痔瘘三科,辽宁沈阳110003

出　　处：《实用临床医药杂志》2023年第10期114-116,123,共4页Journal of Clinical Medicine in Practice

摘　　要：目的观察盐酸洛哌丁胺联合痛泻宁颗粒对腹泻型肠易激综合征(IBS)的临床疗效。方法收集60例腹泻型IBS患者的临床资料,按照治疗方案的不同将患者分为观察组(盐酸洛哌丁胺与痛泻宁颗粒联用)和对照组(盐酸洛哌丁胺单用),每组30例。治疗4周后,评估并比较2组患者治疗前后腹痛评分、腹泻评分、症状总评分。结果治疗前,2组患者腹痛评分、腹泻评分、症状总评分比较,差异无统计学意义(P>0.05);对照组治疗后的腹痛评分、腹泻评分、症状总评分与治疗前比较,差异无统计学意义(P>0.05);治疗后,观察组腹痛评分、腹泻评分、症状总评分均低于治疗前,且均低于对照组,差异有统计学意义(P<0.05)。用药期间,2组患者均未观察到明显不良反应。结论盐酸洛哌丁胺与痛泻宁颗粒联用对腹泻型IBS患者疗效显著,且用药安全性良好。Objective To observe the clinical efficacy of loperamide hydrochloride combined with Tongxiening Granules in the treatment of patients with diarrhea-predominant irritable bowel syndrome(IBS).Methods Clinical materials of 60 patients with diarrhea-predominant IBS were collected,and they were divided into observation group(treated with loperamide hydrochloride and Tongxiening Granules)and control group(treated with loperamide hydrochloride only)according to different therapeutic methods,with 30 cases in each group.After 4 weeks of treatment,the abdominal pain score,diarrhea score and total symptom score before and after treatment were evaluated and compared between two groups.Results Before treatment,there were no significant differences in the abdominal pain score,diarrhea score and total symptom score between the two groups(P>0.05);there were no significant differences in the abdominal pain score,diarrhea score and total symptom score before and after treatment in the control group(P>0.05);after treatment,the abdominal pain score,diarrhea score and total symptom score were significantly lower than those before treatment in the observation group,and these indexes in the observation were also significantly lower than those in the control group(P<0.05).During the medication,no obvious adverse reactions were observed in both groups.Conclusion Loperamide hydrochloride combined with Tongxiening Granules is effective in the treatment of patients with diarrhea-predominant IBS,and the safety of medication is good.

关 键 词：肠易激综合征 腹泻 盐酸洛哌丁胺 痛泻宁颗粒 临床疗效 

分 类 号：R574[医药卫生—消化系统] R453[医药卫生—内科学]