胃癌病人血小板参数和凝血指标与肿瘤远处转移及分期的相关性分析  

Correlation between platelet parameters,coagulation indexes and distant metastasis and stage of gastric cancer

作　　者：吴珊[1] 王冰 WU Shan;WANG Bing(Department of Oncology,The Fourth Affiliated Hospital of Anhui Medical University,Hefei,Anhui 230012,China)

机构地区：[1]安徽医科大学第四附属医院肿瘤科,安徽合肥230012

出　　处：《安徽医药》2023年第7期1404-1408,共5页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探索胃癌病人血小板参数和凝血指标与肿瘤远处转移及TNM分期的相关性。方法选取2018年9月至2021年10月安徽医科大学第四附属医院收治的139例胃癌病人,按照是否存在远处转移分为有远处转移组(56例)和无远处转移组(83例),根据第八版美国癌症联合委员会(AJCC)胃癌分期标准分为Ⅰ期15例、Ⅱ期21例、Ⅲ期47例、Ⅳ期56例,分析血小板参数和凝血指标在两组之间的差异以及与TNM分期的相关性。结果血小板计数有远处转移组[(248.13±87.55)×10^(9)/L]高于无远处转移组[(212.23±77.20)×10^(9)/L];在凝血指标中,纤维蛋白原有远处转移组[(3.66±1.26)g/L]高于无远处转移组[(3.16±0.84)g/L],凝血酶原时间有远处转移组[(11.99±1.06)s]高于无远处转移组[(11.36±0.72)s],部分凝血酶原时间有远处转移组[(26.50±3.96)s]高于无远处转移组[(24.61±3.31)s],国际标准化比值有远处转移组1.03±0.10高于无远处转移组0.97±0.07,与TNM分期呈正相关(P<0.05);凝血酶时间有远处转移组[(17.14±1.11)s]低于无远处转移组[(17.69±1.04)s],与TNM分期呈负相关(P<0.05)。结论胃癌病人血小板参数和凝血指标与肿瘤远处转移及TNM分期有相关性,作为辅助检测手段,有助于预测胃癌病人的转移及病情进展。Objective To explore the correlation of platelet parameters and coagulation indexes with distant metastasis and TNM staging in patients with gastric cancer.Methods A total of 139 gastric cancer patients admitted to the Fourth Affiliated Hospital of Anhui Medical University from September 2018 to October 2021 were selected.According to the existence of distant metastasis,they were divided into distant metastasis group(56 cases)and non-distant metastasis group(83 cases).According to the 8th edition of the American Joint Commission on Cancer(AJCC)staging criteria for gastric cancer,they were divided into stage Ⅰ 15 cases,stage Ⅱ 21 cases,stage Ⅲ 47 cases and stageⅣ56 cases.The differences of platelet parameters and coagulation indexes between the two groups and their correlation with TNM staging were analyzed.Results Platelet count(PLT)in the group with distant metastasis[(248.13±87.55)×10^(9)/L]was higher than that in the group without distant metastasis[(212.23±77.20)×10^(9)/L].Among the coagulation indexes,fibrinogen(FBG)in the group with distant metastasis[(3.66±1.26)g/L]was higher than that in the group without distant metastasis[(3.16±0.84)g/L],prothrombin time(PT)in the group with distant metastasis[(11.99±1.06)s]was higher than that in the group without distant metastasis[(11.36±0.72)s],activated partial thrombopladtin time(APTT)in the group with distant metastasis[(26.50±3.96)s]was higher than that in the group without distant metastasis[(24.61±3.31)s],prothrombin time-international normalized ratio(PT-INR)in the group with distant metastasis 1.03±0.10 was higher than that in the group without distant metastasis 0.97±0.07,the levels of FBG,PT,APTT and PT-IN were positively correlated with TNM staging(P<0.05).Thrombin time(TT)in the group with distant metastasis[(17.14±1.11)s]was lower than that in the group without distant metastasis[(17.69±1.04)s],the level of TT was negatively correlated with TNM staging(P<0.05).Conclusion Platelet parameters and coagulation indexes in patients with

关 键 词：胃肿瘤 血小板计数 纤维蛋白原 凝血酶原时间 肿瘤转移 

分 类 号：R735.2[医药卫生—肿瘤]