额部纤维肉瘤型隆突性皮肤纤维肉瘤1例  

A case of fibrosarcomatous dermatofibrosarcoma protuberans on forehead

作　　者：宋萌萌 谢媛媛 余炳前[2] 骆志成[2] SONG Mengmeng;XIE Yuanyuan;YU Bingqian;LUO Zhicheng(The Second Clinical Medical College of Lanzhou University,Lanzhou,Gansu 730000,China;Department of Dermatology,Lanzhou University Second Hospital,Lanzhou)

机构地区：[1]兰州大学第二临床医学院,甘肃兰州730000 [2]兰州大学第二医院皮肤科,甘肃兰州730030

出　　处：《安徽医药》2023年第7期1446-1448,I0003,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨纤维肉瘤型隆突性皮肤纤维肉瘤(fibrosarcomatous dermatofibrosarcoma protuberans,FS-DFSP)临床特点,以期提高对该病的认识,减少临床误诊。方法回顾性分析2020年7月兰州大学第二医院收治的1例FS-DFSP病人临床资料。结果病人因“额部肿块切除术后10年,再发1年”入院。皮损组织病理:短梭形细胞呈席纹状排列,部分区域呈束状、鱼骨样排列。免疫组化:CD34(+)、波形蛋白(Vimentin)(+)、Ki-67增生活跃区60%(+)。诊断为FS-DFSP,予以扩大范围皮肤病损根治性切除术,术后随访至今未见复发。结论FS-DFSP发病率低,易误诊,提高对该病的认识及警惕性有助于确诊及降低临床误诊率。Objective To investigate the clinical characteristics of fibrosarcomatous dermatofibrosarcoma protuberans(FS-DFSP),in order to improve the understanding of the disease and reduce clinical misdiagnosis.Methods The clinical data of one patient diagnosed as FS-DFSP who admitted to Lanzhou University Second Hospital were retrospectively analyzed in July 2019.Results The patient was admitted to the hospital because a mass on his forehead that recieved excision procedure 10 years ago recurred for more than one year.Histopathology of the skin lesions showed that short spindle cells were arranged in a mat pattern,and some areas were found with bundle-like and fishbone-like arrangement.Immunohistochemical staining showed that CD34(+),Vimentin(+)and Ki-6760%(+).Diagnosis of FS-DFSP was made and extensive radical resection of skin lesions was performed.No recurrence was found in postoperative follow-up up to now.Conclusion The incidence of FS-DFSP is low and it is easy to be misdiagnosed.To improve the awareness and vigilance of FS-DFSP is helpful to diagnose the disease and reduce the rate of clinical misdiagnosis.

关 键 词：皮肤纤维肉瘤 波形蛋白 额部 胶原Ⅰ型 皮脂腺肿瘤 病例报告 

分 类 号：R739.5[医药卫生—肿瘤]